Abstract
Naïve and memory T cells can divide in an antigen-independent manner in vivo maintaining independently a constant pool size. While naïve T cells require TCR tickling by self-MHC for homeostatic proliferation in lymphopenic mice, memory cells do not but respond to cytokines. Human naïve and memory CD4+T cell subsets can be selectively expanded in vitro with different cytokine combinations. Responsiveness of T cells to homeostatic cytokines is associated with the differentiation state. Thus, while memory cells respond directly to IL-7 and IL-15, naïve T cells require costimulation by dendritic cell-derived cytokines, and selectively respond to IL-4. This differential cytokine responsiveness is associated with the expression and modulation of the relevant cytokine receptors. Cytokine-driven proliferation is independent of TCR-stimulation and shows distinct signal transduction requirements. While cytokine-expanded naïve T cells maintain a naïve phenotype, memory cells differentiate acquiring new effector functions and switching expression of chemokine receptors. Thus human naive and memory T cell pools can be maintained with homeostatic cytokines in the absence of TCR stimulation.
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Geginat, J., Campagnaro, S., Sallusto, F. (2002). Tcr-Independent Proliferation and Differentiation of Human Cd4+ T Cell Subsets Induced by Cytokines. In: Gupta, S., Butcher, E., Paul, W. (eds) Lymphocyte Activation and Immune Regulation IX. Advances in Experimental Medicine and Biology, vol 512. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0757-4_14
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DOI: https://doi.org/10.1007/978-1-4615-0757-4_14
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