Abstract
The healthy corneal epithelium has tight junctions and forms a barrier between the environment and the inside of the eye. The tear film aids in protecting the corneal surface, and artificial tear solutions provide temporary relief of dry eye. The tear film is composed of three layers: the lipid, aqueous and mucin layers. The mucin layer, which lies adjacent to the ocular surface, provides an evenly distributed hydrophilic coating on the surface of the cornea. The conjunctival goblet cells1 and corneal and conjunctival epithelial cells continually secrete mucin over the corneal surface. When the outer epithelial layer becomes damaged, the epithelial cells below can produce mucin.2,3 A recent theory is that the secretion of mucin may serve as a method of treating dry eye.
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References
Greiner J, Weidman T, Korb D, Allansmith M. Histochemical analysis of secretory vesicles in nongoblet conjunctival epithelial cells. Acta Ophthalmol. 1985; 63: 89–92.
Ubels J, McCartney M, Lantz W, Beaird J, Dayalan A, Edelhauser H. Effects of preservative-free artificial tear solutions on the corneal epithelial structure and function. Arch Ophthalmol. 1995; 113: 371–378.
Gipson I, Yankaukas M, Spurr-Michaud S, Tisdale A, Rinehart W. Characteristics of glycoprotein in the ocular surface glycocalyx. Invest Ophthalmol Vis Sci. 1992;33: 218–277.
Johnson H, McNee M, Sun F. 15-hydroxyeicosatetraenoic acid is a potent inflammatory mediator and agonist of canine tracheal mucus secretion. Am Rev Respir Dis. 1985; 131: 917–922.
Marom Z, Shelhamer J, Sun F, Kaliner M. Human airway monohydroxy-eicosatetraenoic acid generation and mucus release. J Clin Invest. 1983;72: 122–127.
Copas J, Borgeat P, Gardiner P. The action of 5, 12, and 15 HETE on the tracheobronchial smooth muscle. Prostaglandins Leukot Med. 1982;8: 105–114.
Klyce S, Neufeld A, Zadunaisky J. The activation of chloride transport by epinephrine and Db cyclic-AMP in the cornea of the rabbit. Invest Ophthalmol. 1973;12: 127–139.
Edelhauser H, Rudnick D, Azar R, Corneal epithelial tight junctions and the localization of surface mucin, In Lacrimal Gland, Tear Film and Dry Eye Syndromes 2, D.A. Sullivan, Editor. 1998, Plenum Press: New York. p. 265–271.
Ubels J, Williams K, Lopez-Bernal D, Edelhauser H, Evaluation of effects of a physiological artificial tear on the corneal epithelial barrier: Electrical resistance and carboxyfluorescein permeability, In Lacrimal Gland, Tear Film, and Dry Eye Syndromes, D.A. Sullivan, Editor. 1994, Plenum Press: New York. p. 441–452.
Maurice D. Epithelial potential of the cornea. Exptl Eye Res. 1967;6: 138–140.
Bernai D. Quantitative evaluation of the corneal epithelial barrier: effect of artificial tears and preservatives. CurrEye Res. 1991; 10: 645–656.
Burnstein N, Klyce S. Electrophysiologic and morphologic effects of ophthalmic preparations on the rabbit cornea epithelium. Invest Ophthalmol Vis Sci. 1977; 16: 899–911.
Nichols B, Chiappino M, Dawson C. Demonstration of the mucous layer of the tear film by electron microscopy. Invest Ophthalmol Vis Sci. 1985;26: 464–473.
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© 2002 Kluwer Academic/Plenum Publishers
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Azar, R.G., Edelhauser, H.F. (2002). Evaluation of the Effects of 15(S)-HETE on Corneal Epithelial Cells: An Electrophysiological and Cytochemical Study. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_47
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_47
Publisher Name: Springer, Boston, MA
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