Abstract
The lacrimal gland is responsible for production of many of the major components of the ocular tear fluid. Mucins are important components of the tear film, but the cellular source of these mucins has been uncertain.1 Recently, we showed one of the components produced by the rat lacrimal gland is the mucin Muc4,2 also known as sialomucin complex (SMC). The lacrimal gland produces soluble and membrane forms of Muc4/SMC. The soluble form may contribute to the ocular tear film, but that raises the question of the role of the membrane form in the gland. One of the intriguing aspects of Muc4/SMC is that it has two epidermal growth factor (EGF)-like domains and can act as an intramembrane ligand for the receptor tyrosine kinase ErbB2.3 These characteristics encouraged us to analyze the expression of ErbB2 in the lacrimal gland and determine if an ErbB2-Muc4/SMC complex is present.
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Carraway, K.L., Carvajal, M.E., Li, P., Carraway, C.A.C. (2002). ErbB2 and Its Ligand Muc4 (Sialomucin Complex) in Rat Lacrimal Gland. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_40
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_40
Publisher Name: Springer, Boston, MA
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