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Expression of Vascular Endothelial Growth Factor Receptor-3 (Vegfr-3) in the Conjunctiva-A Potential Link Between Lymphangiogenesis and Leukocyte Trafficking on the Ocular Surface

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 506))

Abstract

Although the lymphatic system penetrates most tissues as a dense network, it has received relatively little attention outside the fields of immunology and vascular biology. The normal cornea is devoid of blood and lymphatic vessels, but a number of corneal stimuli such as contact lens wear, infection, surgical invasion or burns can induce penetration of new vessels from the limbus and conjunctiva into the cornea. The process of growth and development of new blood vessels from preexisting ones is termed angiogenesis, and in the case of lymphatic vessels, lymphangiogenesis.

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Author information

Authors and Affiliations

  1. Schepens Eye Research Institute and the Department of Ophthalmology Harvard Medical School, Laboratory of Immunology, Boston, Massachusetts, USA

    Pedram Hamrah, Qiang Zhang & M. Reza Dana

  2. Massachusetts Eye & Ear Infirmary and Brigham and Women’s Hospital, Cornea Service, Boston, Massachusetts, USA

    M. Reza Dana

Authors
  1. Pedram Hamrah
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  2. Qiang Zhang
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  3. M. Reza Dana
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    David A. Sullivan , Darlene A. Dartt  & Rose M. Sullivan ,  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  3. Allergan, Inc., Irvine, California, USA

    Michael E. Stern

  4. Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  5. Ichikawa General Hospital, Chiba, Japan

    Kazuo Tsubota

  6. University of New Orleans, New Orleans, Louisiana, USA

    B. Britt Bromberg

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© 2002 Kluwer Academic/Plenum Publishers

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Hamrah, P., Zhang, Q., Dana, M.R. (2002). Expression of Vascular Endothelial Growth Factor Receptor-3 (Vegfr-3) in the Conjunctiva-A Potential Link Between Lymphangiogenesis and Leukocyte Trafficking on the Ocular Surface. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_120

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_120

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

  • eBook Packages: Springer Book Archive

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