Skip to main content
SpringerLink
Log in

Oral Immunization of Human with transgenic lettuce Expressing Hepatitis B Surface Antigen

  • Chapter
Progress in Basic and Clinical Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 495))

Abstract

A number of reports for the past few years have shown that higher plants can be important and useful tools for production and delivery of viral antigens. Oral route represents one of the most efficient and safe ways for administration of therapeutic proteins [1]. Among protein antigens expressed in transgenic plants is hepatitis B surface antigen as reported by several laboratories.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Modelska A., Dietzschold B., Sleysh N., Fu Z., Steplewski K., Hooper D., Koprowski H., Yusibov V. (1998) Immunization against rabies with plant-derived antigen. Proc. Natl. Acad. Sci. USA 95, 2481–2485.

    Article  PubMed  CAS  Google Scholar 

  2. Mason H. S., Lam D. M.-K., Arntzen c. J. (1992) Expression of hepatitis B surface antigen in transgenic plants. Proc. Natl. Acad. Sci. USA 89, 11745–11749.

    Article  PubMed  CAS  Google Scholar 

  3. Thanavakam Y., Yang Y.-F., Lyons P., Mason H. S., Amtzen C. (1995) Immunogenicity of transgenic plant-derived hepatitis B surface antigen. Proc. Natl. Acad. Sci. USA 92, 3358­-3361.

    Article  Google Scholar 

  4. Kapusta J., Modelska A., Figlerowicz M., Podkowiiüski J., Pniewski T., Lisowa O., Berbezy P., Helias D., Biesiadka J., Femiak I., Letellier M., Yusibov Y., Plucienniczak A., Koprowski H., Legocki A. B. (1999) Biotechnological approaches•to making vaccine in plants. In: Current Plant Science and Biotechnology in Agriculture. Vol. 36. Plant Biotechnology and in vitro Biology in the 21st Century. Proc. IX Intern. Congress of the Intern. Assoc. of Plant Tissue Culture and Biotechnology. Israel, June 14–19, 1998, Kluwer Acad. Publ. 1999, pp. 571–574.

    Google Scholar 

  5. Kapusta J., Modelska A.., Figlerowicz M., Pniewski T., Letellier M., Lisowa O.; Yusibov Y., Koprowski H., Plucienniczak A., Legocki A. B. (1999) Plant-based edible vaccine against Hepatitis B. FASEB J. 13, 1796–1799.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12, Poznan, 61-704, Poland

    Jozef Kapusta, Anna Modelska, Tomasz Pniewski, Kacper Jankowski, Olesia Lisowa & Andrzej B. Legocki

  2. Institute of Biotechnology and Antibiotics, Staroscinska 5, Warsaw, Poland

    Andrzej Plucienniczak

  3. Marcinkowski Academy of Medical Sciences, Department of Pediatrics, Poznan, Poland

    Magdalena Figlerowicz

  4. Biotechnology Foundation, Thomas Jefferson University, Philadelphia, PA, 19107, USA

    Hilary Koprowski

Authors
  1. Jozef Kapusta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anna Modelska
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tomasz Pniewski
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Magdalena Figlerowicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kacper Jankowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Olesia Lisowa
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Andrzej Plucienniczak
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hilary Koprowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Andrzej B. Legocki
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. GreatPoland Cancer Center, University School of Medical Sciences, Poznan, Poland

    Andrzej Mackiewicz

  2. Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

    Maciej Kurpisz

  3. Department of Immunology, University School of Medical Sciences, Poznan, Poland

    Jan Żeromski

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kapusta, J. et al. (2001). Oral Immunization of Human with transgenic lettuce Expressing Hepatitis B Surface Antigen. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_41

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-0685-0_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5194-8

  • Online ISBN: 978-1-4615-0685-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation