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Lack of Correlation Between CYP2A6 Genotype and Smoking Habits

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Biological Reactive Intermediates VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 500))

Abstract

Nicotine, the primary compound in tobacco that establishes and maintains tobacco dependence, is mainly metabolized to cotinine by polymorphically expressed CYP2A6. Recently it was suggested that individuals lacking fully functional CYP2A6 are significantly protected against becoming tobacco-dependent smokers (Pianezza et al., 1998).

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References

  • Chen, G.F., Tang, Y.M., Green, B., Lin, D.X., Guengerich, F.P., Daly, A.K., Caporaso, N.E., Kadlubar, F.F., 1999, Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method, Pharmacogenetics 9:327–332.

    Article  PubMed  CAS  Google Scholar 

  • Femandez-Salguero, P., Hoffman, S.M.G., Cholerton, C., Mohrenweiser, H., Raunio, H., Rautio, A., Pelkonen, O., Huang, J.D., Evans, W.E., Idle, J.R., Gonzalez, F.J., 1995, A genetic polymorphism of coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles, Am. J. Hum. Genet. 57:651–660.

    Google Scholar 

  • Gullsten, H., Agundez, J.A.G., Benitez, J., Laara, E., Ladero, J.M., Diaz-Rubio, M., Fernandez-Salguero, P., Gonzalez, F., Rautio, A., Pelkonen, O., Raunio, H., 1997, CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis, Pharmacogenetics 7:247–250.

    Article  PubMed  CAS  Google Scholar 

  • Pianezza, M.L., Sellers, E.M., Tyndale, R.F., 1998, Nicotine metabolism defect reduces smoking, Nature 393:750.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Occupational Health, Georg-August-University Göttingen, Waldweg 37, 37073, Göttingen, Germany

    Thomas G. Schulz, Peter Ruhnau & Ernst Hallier

Authors
  1. Thomas G. Schulz
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  2. Peter Ruhnau
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  3. Ernst Hallier
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Editor information

Editors and Affiliations

  1. Université René Descartes, Paris, France

    Patrick M. Dansette

  2. Rutgers University and The Environmental & Occupational Health Sciences Institute, Piscataway, New Jersey, USA

    Robert Snyder

  3. CNRS, Paris, France

    Marcel Delaforge

  4. University of Surrey, Guildford, Surrey, England

    G. Gordon Gibson

  5. Institute of Toxicology and Environmental Health, The Technical University of Munich, Munich, Germany

    Helmut Greim

  6. Medical University of South Carolina, Charleston, South Carolina, USA

    David J. Jollow

  7. University of Texas, Austin, Texas, USA

    Terrence J. Monks

  8. University of Arizona, Tucson, Arizona, USA

    I. Glenn Sipes

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© 2001 Springer Science+Business Media New York

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Schulz, T.G., Ruhnau, P., Hallier, E. (2001). Lack of Correlation Between CYP2A6 Genotype and Smoking Habits. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_29

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  • DOI: https://doi.org/10.1007/978-1-4615-0667-6_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5185-6

  • Online ISBN: 978-1-4615-0667-6

  • eBook Packages: Springer Book Archive

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