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Cytokine Regulation in Major Depression

  • Chapter
Cytokines and Mental Health

Part of the book series: Neurobiological Foundation of Aberrant Behaviors ((NFAB,volume 7))

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Abstract

Two decades have now elapsed since the first reports of immune abnormalities in patients with major depression have been published (1–4). While these early reports were generally well received, there was a good deal of skepticism regarding their clinical significance (5). With the very rapid growth of research in the field of psychoneuroimmunology that followed (6) new meaning and new insights have been added to the neuroimmunology of affective disorders. More specifically, the explosion in cytokine research over the last decade or so and the role these cytokines may play in various neurochemical, neuroendocrine and behavioral phenomena have offered new possibilities for a role for cytokines in major depression. This review will first examine the evidence for immune dysregulation in major depression in general, and will then focus on cytokine dysregulation in particular. A critical review of the "cytokine hypothesis" of major depression will then follow.

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  1. Department of Psychiatry, University of Michigan Health System, Ann Arbor, Michigan , USA

    Ziad Kronfol

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    Ziad Kronfol

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Kronfol, Z. (2003). Cytokine Regulation in Major Depression. In: Kronfol, Z. (eds) Cytokines and Mental Health. Neurobiological Foundation of Aberrant Behaviors, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0323-1_12

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