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Calcium Signaling by cADPR in Cardiac Myocytes

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Cyclic ADP-Ribose and NAADP

Abstract

The heart is a muscular organ, composed of electrically connected excitable cells that act in a coordinated, syncytial fashion to pump blood to the other tissues of the body. Since Ringer’s observation in 1883 that Ca2+ is essential for contraction of the heart [1], major advancements have been made in elucidating the mechanisms by which electrical excitation of the myocardium (the cardiac action potential, initiated by the pacemaker region) is linked to mechanical contraction of the heart, and it is now well established that Ca2+ ions play the fundamental role in this coupling of excitation to contraction.

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Authors and Affiliations

  1. Department of Pharmacology, Oxford University, Mansfield Road, Oxford, OX1 3QT, UK

    Stevan Rakovic & Derek A Terrar

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  1. Stevan Rakovic
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  2. Derek A Terrar
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  1. Minneapolis, USA

    Hon Cheung Lee

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Rakovic, S., Terrar, D.A. (2002). Calcium Signaling by cADPR in Cardiac Myocytes. In: Lee, H.C. (eds) Cyclic ADP-Ribose and NAADP. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0269-2_15

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  • DOI: https://doi.org/10.1007/978-1-4615-0269-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4996-9

  • Online ISBN: 978-1-4615-0269-2

  • eBook Packages: Springer Book Archive

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