Abstract
Cancer associated retinopathy (CAR) is an ocular manifestation of paraneoplastic syndrome clinically characterized by progressive visual impairment similar to retinitis pigmentosa. As a possible mechanism causing the retinal degeneration, the presence of serum autoantibodies against recoverin and other retinal antigens are involved. The molecular pathology in CAR by anti-recoverin antibody is considered to occur in the following steps: Firstly, recoverin aberrantly expressed in cancerous tissues is recognized by immunocytes by some unknown mechanisms and then a specific antibody toward recoverin is produced. Secondly, the anti-recoverin antibody reaches the retina via the peripheral circulation and is taken up into photoreceptor cells. Lastly, the antibody blocks recoverin function (inhibition of rhodopsin phosphorylation in a calcium dependent manner), and enhancement of rhodopsin phosphorylation induces retinal apoptosis.
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© 2002 Springer Science+Business Media New York
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Ohguro, H., Nakazawa, M. (2002). Pathological Roles Of Recoverin In Cancer-Associated Retinopathy. In: Baehr, W., Palczewski, K. (eds) Photoreceptors and Calcium. Advances in Experimental Medicine and Biology, vol 514. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0121-3_7
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DOI: https://doi.org/10.1007/978-1-4615-0121-3_7
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