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Ca2+Regulation ofDrosophilaPhototransduction

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Photoreceptors and Calcium

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 514))

Abstract

Drosophilavision research has benefited from simultaneous application of genetic, molecular, electrophysiological analyses. The work establishes an essential role of Ca2+in regulation of phototransduction. Many different proteins are the targets of Ca2+regulation and these proteins act at multiple steps of the process. These targets include proteins involved in the rhodopsin cycle, proteins responsible for intermediate steps of phototransduction, and the TRP and TRPL light-gated channels. The regulation of these phototransduction components by Ca2+occurs in three different ways. First, the presence of Ca2+/calmodulin-binding sites in phototransduction-mediating proteins places these proteins under Ca2+control. Second, a protein kinase C regulated by Ca2+phosphorylates proteins to modulate their activity. Finally, some proteins contain Ca2+-binding sites and apparently are directly regulated by Ca2+. Here I review the photoreceptor proteins regulated by Ca2+and summarize current views on the roles of these proteins in theDrosophilaphotoresponse.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA

    Joseph O’Tousa

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  1. Moran Eye Center/EIHG, University of Utah Health Science Center, 15 North/ 2030 East, Salt Lake City, UT, 84112-5330, USA

    Wolfgang Baehr Ph.D.

  2. Department of Ophthalmology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA

    Krzysztof Palczewski Ph.D.

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O’Tousa, J. (2002). Ca2+Regulation ofDrosophilaPhototransduction. In: Baehr, W., Palczewski, K. (eds) Photoreceptors and Calcium. Advances in Experimental Medicine and Biology, vol 514. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0121-3_30

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  • DOI: https://doi.org/10.1007/978-1-4615-0121-3_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4933-4

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