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Modeling of Oxygen Diffusion from the Blood Vessels to Intracellular Organelles

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Oxygen Transport to Tissue XXIV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 530))

Abstract

We describe recent models of oxygen transport in tissue along the pathwayfrom the hemoglobin molecule to the mitochondria and illustrate their applications. Microvasculature is the major site of exchange between blood and parenchymal cells for gases (O2, CO2, CO, NO), nutrients, metabolic products, and drugs. These exchange processes are affected by the architecture of the microvessels and the surrounding cells; distribution of blood flow; transport characteristics of blood, cells, and interstitial space; and rates of various chemical reactions associated with the transport processes. These processes operate at multiple levels of biological organization, from the molecular to the organ levels. Quantitative understanding of molecular transport in cells and tissues, specifically of oxygen transport, is the prerequisite for understanding the mechanisms of many diseases and for designing effective therapies. Mathematical and computational models provide a powerful set of tools for studies of these complex phenomena.

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Authors and Affiliations

  1. Department of Biomedical Engineering and Center for Computational Medicine and Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Aleksander S. Popel, Daniel Goldman & Arjun Vadapalli

Authors
  1. Aleksander S. Popel
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  2. Daniel Goldman
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  3. Arjun Vadapalli
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Editor information

Editors and Affiliations

  1. Dartmouth Medical School, Hanover, New Hampshire, USA

    Jeffrey F. Dunn  & Harold M. Swartz  & 

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© 2003 Springer Science+Business Media New York

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Popel, A.S., Goldman, D., Vadapalli, A. (2003). Modeling of Oxygen Diffusion from the Blood Vessels to Intracellular Organelles. In: Dunn, J.F., Swartz, H.M. (eds) Oxygen Transport to Tissue XXIV. Advances in Experimental Medicine and Biology, vol 530. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0075-9_46

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  • DOI: https://doi.org/10.1007/978-1-4615-0075-9_46

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4912-9

  • Online ISBN: 978-1-4615-0075-9

  • eBook Packages: Springer Book Archive

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