Abstract
In recent years, advancement in the development of gene transfer techniques as well as identification of target genes for numerous disorders of both acquired and inherited nature has driven an explosion of published work in the field of gene therapy. Gene therapy has enormous potential to provide new treatments that strike directly at the heart of molecular defects to produce the next generation of molecular medicines in diseases for which current therapy is insufficient or absent.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Isner, J. M., Vale, P. R., Symes, J. F. and Losordo, D. W. (2001)Circ. Res. 89, 389–400.
Herz, J. and Gerard, R. D. (1993) Proc. Nat. Acad. Sci. U.S.A. 90, 2812–2816.
Kozarsky, K. F., Jooss, K., Donahee, M., Strauss, J. F. and Wilson, J. M. (1996)Nature Genet. 13, 54–62.
Stevenson, S. C., Marshall-Neff, J., Teng, B., Lee, C. B., Roy, S. and McClelland, A.(1995) Arterio. Thromb. Vasc. Biol. 15, 479–484.
Grossman, M., Radr, D. J., Muller, D. W. M., Kolansky, D. M., Kozarsky, K., Clark, B. J., Stein, E. A., Lupien, P. J., Brewer, H. B., Raper, S. E. and Wilson, J. M. (1995)Nature Med. 1, 1148–1154.
Grossman, H., Raper, S. E., Kozarsky, K., Stein, E. A., Engelhardt, J., Muller, D. W. M.,Lupien, P. J. and Wilson, J. M. (1994)Nature Genet. 6, 335–344.
Spady, D. K., Cuthbert, J. A., Willard, M. N. and Meidell, R. S. (1995)J. Clin. Invest. 96,700–709.
Morishita, R., Yamada, S., Yamamoto, K., Tomita, N., Kida, I., Sakurabayashi, I., Kikuchi, A., Kaneda, Y., Lawn, R., Higaki, J. and Ogihara, T. (1998)Circulation 98, 1898–1904.
Oka, K., Pastore, L., Kim, I. H., Merched, A., Nomura, S., Lee, H. J., Merched-Sauvage, M., Arden-Riley, C., Lee, B., Finegold, M., Beaudet, A. and Chan, L. (2001)Circulation 103,1274–81.
Chen, S.-J., Rader, D. J., Tazelaar, J., Kawashiri, M.-A., Gao, G.-P. and Wilson, J. M.(2001)Mol. Ther. 2, 256–261.
Kim, I.-H., Jozkowicz, A., Piedra, P. A., Oka, K. and Chan, L. (2001) Proc. Nat. Acad.Sci. U.S.A. 98, 13282–13287.
Huard, J., Lochmuller, H., Acsadi, G., Jani, A., Massie, B. and Karpati, G. (1995)Gene Ther. 2, 107–115.
Kochanek, S., Clemens, P. R., Mitani, K., Chen, H.-H., Chan, S. and Caskey, C. T.(1996) Proc. Nat. Acad. Sci. U.S.A. 93, 5731–5736.
Kochanek, S. (1999)Hum. Gene Ther. 10, 2451–2459.
Qiao, J. H., Xie, P. Z., Fishbein, M. C., Kreuzer, J., Drake, T. A., Demer, L. L. and Lusis,A. J. (1994) Arterio. Thromb. Vasc. Biol. 14, 1480–1497.
Grines, C. L., Watkins, M. W., Helmer, G., Penny, W., Brinker, J., Marmur, J. D., West, A., Rade, J. J., Marrott, P., Hammond, H. K. and Engler, R. L. (2002)Circulation 105, 1291–1297.
Chang, M. W., Barr, E., Seltzer, J., Jiang, Y.-Q., Nabel, G. J., Nabel, E. G., Parmacek, M.S. and Leiden, J. M. (1995)Science 267, 518–522.
Yang, Z.-Y., Simari, R. D., Perkins, N. D., San, H., Gordon, D., Nabel, G. J. and Nabel,E. G. (1996) Proc. Nat. Acad. Sci. U.S.A. 93, 7905–7910.
George, S. J., Johnson, J. L., Angelini, G. D., Newby, A. C. and Baker, A. H. (1998)Hum. Gene Ther. 9, 867–877.
George, S. J., Baker, A. H., Angelini, G. D. and Newby, A. C. (1998)Gene Ther. 5,1552–1560.
George, S. J., Angelini, G. D., Capogrossi, M. C. and Baker, A. H. (2001)Gene Ther. 8,668–76.
Baker, A. H., Zaltsman, A. B., George, S. J. and Newby, A. C. (1998)J. Clin. Invest.101, 1478–1487.
George, S. J., Lloyd, C. T., Angelini, G. D., Newby, A. C. and Baker, A. H. (1999)Circulation 101, 296–304.
Mann, M. J., Whittemore, A. D., Donaldson, M. C., Belkin, M., Conte, M. S., Polak, J. F., Orav, E. J., Ehsan, A., Dell’Acqua, G. D. and Dzau, V. (1999)The Lancet 354, 1493–1498.
Mann, M. J. and Dzau, V. J. (2000)J. Clin. Invest. 106, 1071–5.
Campeau, L., Enjalbert, M., Lesperance, J., Vaislic, C., Grondin, C. M. and Bourassa, M.G. (1983)Circulation 68 (suppl. II), 1–7.
Wang, C., Chao, L. and Chao, J. (1995)J. Clin. Invest. 95, 1710–1716.
Lin, K., Chao, L. and Chao, J. (1997)Hypertension 30, 307–313.
Mohuczy, D., Gelband, C. H. and Phillips, I. M. (1999)Hypertension 33 (part II), 354–359.
Zoldhelyi, P., McNatt, J., Xu, X.-M., Loose-Mitchell, D., Meidell, R. S., Clubb, F. J.,Buja, M., Willerson, J. T. and Wu, K. K. (1996)Circulation 93, 10–17.
Numaguchi, Y., Naruse, K., Harada, M., Osanai, H., Mokuno, S., Murase, K., Matsui, H., Toki, Y., Ito, T., Okumura, K. and Hayakawa, T. (1999) Arterio. Thromb. Vasc. Biol. 19, 727–733.
Vassalli, G. and Dichek, D. A. (1998) in Principles of Molecular Medicine (Jameson, J.L., ed.), pp. 161–168, Humana Press Inc., Totowa, NJ.
Baker, A., Mehta, D., George, S. J. and Angelini, G. D. (1997)Cardiovasc.Res. 35, 442–450.
Francis, S. C., Raizada, M. K., Mangi, A. A., Melo, L. G., Dzau, V. J., Vale, P. R., Isner, J. M., Losordo, D. W., Chao, J., Katovich, M. J. and Berecek, K. H. (2001)Physiol. Genomics 7, 79–94.
Khurana, R., Martin, J. F. and Zachary, I. (2001)Hypertension 38, 1210–1216.
Reissen, R., Rahimizadeh, H., Blessing, E., Takeshita, S., Barry, J. J. and Isner, J. M.(1993)Hum. Gene Ther. 4, 749–758.
Nabel, E. G., Yang, Z., Liptay, S., San, H., Gordon, D., Haudenschild, C. C. and Nabel,G. J. (1993)J. Clin. Invest. 91, 1822–1829.
Nabel, E. G., Yang, Z., Plautz, G., Forough, R., Zhan, X., Haudenshild, C. C., Maciag, T.and Nabel, G. J. (1993)Nature 362, 844–846.
Nabel, E. G., Shum, L., Pompili, V. J., Yang, Z. Y., San, H., Shu, H. B., Liptay, S., Gordon, D., Derynck, R. and Nabel, G. J. (1993) Proc. Nat. Acad. Sci. U.S.A. 90, 10759–10763.
Takeshita, S., Tsurumi, Y., Couffinahl, T., Asahara, T., Bauters, C., Symes, J., Ferrara,N. and Isner, J. M. (1996)Lab. Invest. 75, 487–501.
Baumgartner, I., Pieczek, A., Manor, O., Blair, R., Kearney, M., Walsh, K. and Isner, J.M. (1998)Circulation 97, 1114–1123
Losordo, D. W., Vale, P. R., Symes, J. F., Dunnington, C. H., Esakof, D. D., Maysky, N.,Ashare, A. B., Lathi, K. and Isner, J. M. (1998)Circulation 98, 2800–2094.
Vale, P. R., Losordo, D. W., Milliken, C. E., Maysky, M., Esakof, D. D., Symes, J. F. and Isner, J. M. (2000)Circulation 102, 965–974.
Vale, P. R., Losordo, D. W., Milliken, C. E., McDonald, M. C., Gravelin, L. M., Curry, C. M., Esakof, D. D., Maysky, M., Symes, J. F. and Isner, J. M. (2001)Circulation 103, 2138–2143.
Lee, R. J., Springer, M. L., Blanco-Bose, W. E., Shaw, R., Ursell, P. C. and Blau, H. M.(2000)Circulation 102, 898–901.
Lawrie, A., Brisken, A. F., Francis, S. E., Tayler, D. I., Chamberlain, J., Crossman, D. C.,Cumberland, D. C. and Newman, C. M. (1999)Circulation 99, 2617–2620.
Lawrie, A., Brisken, A. F., Francis, S. E., Cumberland, D. C., Crossman, D. C. and Newman, C. M. (2000)Gene Ther. 7, 2023–2027.
Taniyama, Y., Tachibana, K., Hiraoka, K., Namba, T., Yamasaki, K., Hashiya, N., Aoki, M., Ogihara, T., Yasufumi, K. and Morishita, R. (2002)Circulation 105, 1233–1239.
Feigner, P. L. and Ringold, G. M. (1989)Nature 337, 387–338.
Stephan, D. J., Yang, Z. Y., San, H., Simari, R. D., Wheeler, C. J., Felgrer, P. L., Gordon,D., Nabel, G. J. and Nabel, E. G. (1996)Hum. Gene Ther. 7, 1803–1812.
Muller, D. W., Gordon, D., San, H., Yang, Z., Pompili, V. J., Nabel, G. J. and Nabel, E.G. (1994)Circ. Res. 75, 1039–1049.
Tanner, F. C., Carr, D. P., Nabel, G. J. and Nabel, E. G. (1997)Cardiovasc. Res. 35, 522–528.
Leclerc, G., Gal, D., Takeshita, S., Nikol, S., Weir, L. and Isner, J. M. (1992)J. Clin.Invest. 90, 936–944.
Nabel, E. G., Plautz, G. and Nabel, G. J. (1990)Science 249, 1285–1288.
Plautz, G., Nabel, E. G. and Nabel, G. J. (1991)Circulation 83, 578–583.
Forough, R., Koyama, N., Hasentab, D., Lea, H., Clowes, M., Nikkari, S. T. and Clowes,A. W. (1996)Circ. Res. 79, 812–820.
Cioffi, L., Sturtz, F. G., Wittmer, S., Barut, B., Smith-Gbur, J., Moore, V., Zupanic, T., Gilligan, B., Auerbach, R., Gomez, F., Chauvin, F., Antczak, M., Platika, D. and Snodgrass, H. R. (1999)Gene Ther. 6, 1153–1159.
Anderson, W. F. (1984)Science 226, 401–409.
Eglitis, M. A., Kantoff, P. W., Gilboa, E. and Anderson, W. F. (1985)Science 230, 1395–1398.
Friedman, T. (1989)Science 244, 1275–1281.
Hock, R. A. and Miller, A. D. (1986)Nature 320, 275–277.
Miller, D. G., Adam, M. A. and Miller, A. D. (1990)Mol. Cell Biol. 10, 4239–4242.
Herzog, R. W., Yang, E. Y., Couto, L. B., Hagstrom, J. N., Elwell, D., Fields, P. A., Burton, M., Bellinger, D. A., Read, M. S., Brinkhous, K. M., Podsakoff, G. M., Nichols, T. C., Kurtzman, G. J. and High, K. A. (1999)Nature Med. 5, 56–63.
Snyder, R. O., Miao, C., Meuse, L., Tubb, J., Donahue, A. R., Lin, H.-F., Stafford, D. W., Patel, S., Thompson, A. R., Nichols, T., Read, M. S., Bellinger, D. A., Brinkhous, K. M. and Kay, M. A. (1999)Nature Med. 5, 64–70.
Lynch, C. M., Hara, P. S., Leonard, J. C., Koudy Williams, J., Dean, R. H. and Geary, R.L. (1997)Circ. Res. 80, 497–505.
Maeda, Y., Ikeda, U., Ogasawara, Y., Urabe, M., Takizawa, T., Saito, T., Colosi, T.,Kurtzman, G., Shimada, K. and Ozawa, K. (1997)Cardiovasc. Res. 35, 514–521.
Richter, M., Iwata, A., Nyhuis, J., Nitta, Y., Miller, A. D., Halbert, C. L. and Allen, M. D. (2000)Physiol. Genomics 2, 117–127.
Su, H., Lu, R. and Kan, Y. W. (2000) Proc. Nat. Acad. Sci. U.S.A. 97, 13801–13806.
Shimpo, M., Ikeda, U., Maeda, Y., Takahashi, M., Miyashita, H., Mizukami, H., Urabe, M., Kume, A., Takizawa, T., Shibuya, M., Ozawa, K. and Shimada, K. (2002)Cardiovasc. Res. 53, 993–1001.
Kawada, T., Nakazawa, M., Nakauchi, S., Yamazaki, K., Shimamoto, R., Urabe, M., Nakata, J., Hemmi, C., Masui, F., Nakajima, T., Suzuki, J.-I., Monahan, J., Sato, H., Masaki, T., Ozawa, K. and Toyo-oka, T. (2002) Proc. Nat. Acad. Sci. U.S.A. 99, 901–906.
Melo, L. G., Agrawal, R., Zhang, L., Rezvani, M., Mangi, A. A., Ehsan, A., Griese, D. P., Dell’Acqua, G., Mann, M. J., Oyama, J., Yet, S.-F., Layne, M. D., Perrella, M. A. and Dzau, V. J. (2002)Circulation 105, 602–607.
Merrick, A. F., Shewring, L. D., Sawyer, G. J., Gustafsson, K. T. and Fabre, J. W. (1996)Transplantation 62, 1085–1089.
Jaffe, H. A., Danel, C., Cid, M. C., Kleinman, H. K., StratfordPavirani, A., Le Cocq, J.-P. and Crystal, R. G. (1992)Proc. Nat. Acad.72 6482–6486.
Jones, M., Yamada, I. and Crystal, R. G. (1993)Circ. Res. 72(5), 1132–1138.
Channon, K. M., Qian, H., Youngblood, S. A., Olmez, E., Shetty, G. A., Neplioueva, V.,Blazing, M. A. and George, S.E. (1998)Circ. Res. 82, 1253–1262.
Yang, Y., Nunes, F. A., Berencsi, K., Furth, E. E., Gönczol, E. and Wilson, J. M. (1994)Proc. Nat. Acad. Sci. U.S.A. 91, 4407–4411.
Yang, Y., Li, Q., Ertl, H. C. J., and Wilson, J. M. (1995)J. Virol. 69, 2004–2015.
Yang, Y., Su, Q. and Wilson, J. M. (1996)J. Virol. 70, 7209–7212.
Hiltunen, M. O., Turunen, M. P., Turunen, A.-M., Rissanen, T. T., Laitinen, M., Kosma,V.-M. and Yla-Herttuala, S. (2000)FASEB J. 14, 2230–2236.
Gladson, C. L. and Cheresh, D. A. (1994) in Integrins: the Biological Problems (Takada,Y., ed.), pp. 83–99, CRC Press, Boca Raton, FL.
Pasqualini, R., Koivunen, E. and Ruoslahti, E. (1995)J. Cell Biol. 130, 1189–1196.
Wilson, D. R. and Finlay, B. B. (1998)Canad. J. Microbiol. 44, 313–329.
Smith, G. P. (1985)Science 228, 1315–1317.
Cwirla, S. E., Peters, E. A., Barrett, R. W. and Dower, W. J. (1990)Proc. Nat. Acad. Sci.U.S.A. 87, 6378–6382.
Devlin, J. J., Panganiban, L. C. and Devlin, P. E. (1990)Science 249, 404–406.
Scott, J. K. and Smith, G. P. (1990)Science 228, 1315–1317.
Smith, G. P. (1993)Gene 128, 1–2.
Luzzago, A., Felici, F., Tramontano, A., Pessi, A. and Cortese, R. (1993)Gene 128, 51–57.
McLafferty, M. A., Kent, R. B., Ladner, R. C. and Markland, W. (1993)Gene 128, 29–36.
Wrighton, N. C., Farrell, F. X., Chang, R., Kashyap, A. K., Barbone, F. P., Mulcahy, L. S., Johnson, D. L., Barrett, R. W., Jolliffe, L. K. and Dower, W. J. (1996)Science 273, 458–464.
Pasqualini, R. and Ruoslahti, E. (1996)Nature 380, 364–366.
Pasqualini, R., Koivunen, E. and Ruoslahti, E. (1997)Nature Biotechnol. 15, 542–546.
Rajotte, D., Arap, W., Hagedorn, M., Koivunen, E., Pasqualini, R. and Ruoslahti, E.(1998)J. Clin. Invest. 102, 430–437.
Arap, W., Pasqualini, R. and Ruoslahti, E. (1998)Science 279, 377–380.
Burg, M. A., Pasqualini, R., Arap, W., Ruoslahti, E. and Stallcup, W. B. (1999)Cancer Res. 59, 2869–2874.
Ruoslahti, E. and Rajotte, D. (2000)Annu. Rev. Immunol. 18, 813–827.
Essler, M. and Ruoslahti, E. (2002) Proc. Nat. Acad. Sci. U.S.A. 99, 2252–2257.
Arap, W., Haedicke, W., Bernascni, M., Kain, R., Rajotte, D., Krajewski, S., Ellerby, H. M., Bredesen, D. E., Pasqualini, R. and Ruoslahti, E. (2002) Proc. Nat. Acad. Sci. U.S.A. 99,1527–1531.
Arap, W., Kolonin, M. G., Trepel, M., Landenranta, J., Cardo-Vila, M., Giordano, R. J., Mintz, P. J., Ardelt, P. U., Yao, V. J., Vidal, C. I., Chen, L., Flamm, A., Valtanen, H., Weavind, L. M., Hicks, M. E., Pollock, R. E., Botz, G. H., Bucana, C. D., Koivunen, E., Cahill, D., Troncoso, P., Baggerly, K. A., Pentz, R. D., Do, K.-A., Logothetis, C. J. and Pasqualini, R. (2002)Nature Med. 8, 121–127.
Michon, I. N., Hauer, A. D., von der Thüsen, J. H., Molenaar, T. J. M., van Berke], T. J.C., Biessen, E. A. L. and Kuiper, J. (2002) Biochim. Biophys. Acta 1591, 87–97.
Hermann, A., Pieper, M. and Schrader, J. (1999) Biochim. Biophys. Acta 1472, 529–536.
Houston, P., Goodman, J., Lewis, A., Campbell, C. J. and Braddock, M. (2001) FEBS Letts. 246–351 5.
Nicklin, S. A., White, S. J., Watkins, S. J., Hawkins, R. E. and Baker, A. H. (2000)Circulation 102, 231–237.
Nicklin, S. A., Buening, H., Dishart, K. L., de Alwis, M., Girod, A., Hacker, U., Thrasher, A. J., Ali, R. R., Hallek, M. and Baker, A. H. (2001)Mol. Ther. 4, 174–181.
Nicklin, S. A., Von Seggern, D. J., Work, L. M., Pek, D. C. K., Dominiczak, A. F., Nemerow, G. R. and Baker, A. H. (2001)Mol. Ther. 4, 534–542.
Xia, H., Anderson, B., Mao, Q. and Davidson, B. L. (2000)J. Virol. 74, 11359–11366.
Bergelson, J. M., Cunningham, J. A., Droguett, G., Kurt-Jones, E. A., Krithivas, A., Hong, J. S., Horwitz, M. S., Crowell, R. L. and Finberg, R. W. (1997)Science 275, 1320–1323.
Tomko, R. P., Xu, R. and Philipson, L. (1997) Proc. Nat. Acad. Sci. U.S.A. 94, 3352–3356.
Wickham, T. J., Mathias, P., Cheresh, D. A. and Nemerow, G. R. (1993)Cell 73, 309–319.
Wickham, T. J., Filardo, E. J., Cheresh, D. A. and Nemerow, G. R. (1994)J. Cell Biol.124,257–264.
Hackett, N. R., El Sawy, T., Lee, L. Y., Silva, I., O’Leary, J., Rosengart, T. K. And Crystal, R. G. (2000)Mol. Ther. 2, 649–656.
Doukas, J., Hoganson, D.K., Ong, M., Ying, W., Lacey, D.L., Baird, A., Pierce, G.F. and Sosnowski, B.A.A. (1999)FASEB J. 13, 1459–1466.
Wickham, T. J., Segal, D. M., Roelvink, P. W., Carrion, M. E., Lizonova, A., Lee, G. M. and Kovesdi, I. (1996)J. Virol. 70(10), 6831–6838.
Watkins, S. J., Mesyanzhinov, V., Kurochkina, L. P. and Hawkins, R. E. (1997)Gene Ther. 4, 1004–1012.
Harari, O. A., Wickham, T. J., Stocker, C. J., Kovesdi, I., Segal, D. M., Huehns, T. Y., Sarraf, C. and Haskard, D. O. (1999)Gene Ther. 6, 801–807.
Nettelbeck, D. M., Miller, D. W., Jerome, V., Zuzarte, M., Watkins, S. J., Hawkins, R.E., Muller, R. and Kontermann, R. E. (2001)Mol. Ther. 3, 882–891.
Trepel, M., Grifman, M., Weitzman, M. D. and Pasqualini, R. (2000)Hum. Gene Ther. 11,1971–1981.
Trepel, M., Arap, W. and Pasqualini, R. (2000)Gene Ther. 7, 2059–60.
Reynolds, P. N., Zinn, K. R., Gavrilyuk, V. D., Balyasnikova, I. V., Rogers, B. E., Buchsbaum, D. J., Wang, M. H., Miletich, D. J., Grizzle, W. E., Douglas, J. T., Danilov, S. M. and Curiel, D. T. (2000)Mol. Ther. 2, 562–578.
Caldwell, P. R., Seegal, B. C., Hsu, K. C., Das, M. and Soffer, R. L. (1976)Science 191,1050–1051.
Schuster, D. P., Crouch, E. C., Parks, W. C., Johnson, T. and Botney, M. D. (1996)Amer. J. Resp. Crit. Care Med. 154, 1087–1091.
Nicklin, S. A., Reynolds, P. N., Brosnan, M. J., White, S. J., Curiel, D. T., Dominiczak,A. F. and Baker, A. H. (2001)Hypertension 38, 65–70.
Reynolds, P. N., Nicklin, S. A., Kaliberova, L., Boatman, B. G., Grizzle, W. E., Balyasnikova, I., Baker, A. H., Danilov, S. M. and Curiel, D. T. (2001)Nature Biotechnol. 19, 838–842.
Krasnykh, V. N., Mikheeva, G. V., Douglas, J. T. and Curiel, D. T. (1996)J. Virol. 70,6839–6846.
Su, E. J., Stevenson, S. C., Rollence, M., Marshall-Neff, J. and Liau, G. (2001)J. Vast.Res. 38, 471–478.
Havenga, M. J. E., Lemckert, A. A. C., Grimbergen, J. M., Vogels, R., Huisman, L. G.M., Valerio, D., Bout, A. and Quax, P. H. A. (2001)J. Virol. 75, 3335–3342.
Chillon, M., Bosch, A., Zabner, J., Law, L., Armentano, D., Welsh, M. J. and Davidson, B. L. (1999)J. Virol. 73, 2537–2540.
Xia, D., Henry, L. J., Gerard, R. D. and Deisenhofer, J. (1994)Structure 2, 1259–1270.
Kirby, I., Davison, E., Beavil, A. J., Soh, C. P. C., Wickham, T. J., Roelvink, P. W.,Kovesdi, L., Sutton, B. J. and Santis, G. (1999)J. Virol. 73, 9508–9514.
Kirby, I., Davidson, E., Beavil, A. J., Soh, C. P. C., Wickham, T. J., Roelvink, P. W.,Kovesdi, I., Sutton, B. J. and Santis, G. (2000)J. Virol. 74, 2804–2813.
Roelvink, P. W., Lee, G. M., Einfeld, D. A., Kovesdi, I. and Wickham, T. J. (1999)Science 286, 1568–1571.
Micheal, S. I., Hong, J. S., Curiel, D. T. and Engler, J. A. (1995) Gene Ther. 2, 660–668.
Wickham, T. J., Roelvink, P. W., Brough, D. E. and Kovesdi, L. (1996)Nature Biotechnol. 14, 1570–1573.
Wickham, T. J., Tzeng, E., Shears II, L. L., Roelvink, P. W., Li, Y., Lee, G. M., Brough, D. E., Lizonova, A. and Kovesdi, I. (1997)J. Virol. 71, 8221–8229.
Krasnykh, V., Dmitriev, I., Mikheeva, G., Miller, R., Belousova, N. and Curiel, D. T.(1998)J. Virol. 72, 1844–1852.
Dmitriev, I., Krasnykh, V., Miller, C. R., Wang, M., Kashentseva, E., Mikheeva, G.,Belousova, N. and Curiel, D. T. (1998)J. Virol. 72, 9706–9713.
Cripe, T. P., Dunphy, E. J., Holub, A. D., Saini, A., Vasi, N. H., Mahller, Y. Y., Collins, M. H., Snyder, J. D., Krasnykh, V., Curiel, D. T., Wickham, T. J., DeGregori, J., Bergelson, J. M. and Currier, M. A. (2001)Cancer Res. 61, 2953–2960.
Okada, N., Tsukada, Y., Nakagawa, S., Mizuguchi, H., Mori, K., Saito, T., Fujita, T., Yamamoto, A., Hayakawa, T. and Mayumi, T. (2001) Biochem. Biophys. Res. Commun. 282,173–179.
Garcia-Castro, J., Segovia, J. C., Garcia-Sanchez, F., Lillo, R., Gomez-Navarro, J., Curiel, D. T. and Bueren, J. A. (2001)Mol. Ther. 3, 70–77.
Wesseling, J. G., Bosma, P. J., Krasnykh, V., Kashentseva, E. A., Blackwell, J. L., Reynolds, P. N., Li, H., Parameshwar, M., Vickers, S. M., Jaffee, E. M., Huibregtse, K., Curiel, D. T. and Dmitriev, I. (2001)Gene Ther. 8, 969–976.
Kanerva, A., Wang, M., Bauerschmitz, G. J., Lam, J. T., Desmond, R. A., Bhoola, S. M., Barnes, M. N., Alvarez, R. D., Siegal, G. P., Curiel, D. T. and Hemminki, A. (2002)Mol. Ther. 5, 695–704.
Nakamura, T., Sato, K. and Hamada, H. (2002)Hum. Gene Ther. 13, 613–626.
Hay, C. M., De Leon, H., Jafari, J. D., Jakubczak, J. L., Mech, C. A., Hallenbeck, P. L., Powell, S. K., Liau, G. and Stevenson, S. C. (2001)J. Vase. Res. 38, 315–323.
Vigne, E., Mahfouz, I., Dedieu, J.-F., Brie, A., Perricaudet, M. and Yeh, P. (1999)J. Virol. 73, 5156–5161.
Jakubczak, J. L., Rollence, M. L., Stewart, D. A., Jafari, J. D., Von Seggern, D. J., Nemerow, G. R., Stevenson, S. C. and Hallenbeck, P. L. (2001)J. Virol. 75, 2972–2981.
Leissner, P., Legrand, V., Schlesinger, Y., Hadji, D. A., van Raaij, M., Cusack, S., Pavirani, A. and Mehtali, M. (2001)Gene Ther. 8, 49–57.
Alemany, R. and Curiel, D. T. (2001)Gene Ther. 8, 1347–1353.
Einfeld, D. A., Schroeder, R., Roelvink, P. W., Lizonova, A., King, C. R., Kovesdi, I. and Wickham, T. J. (2001)J. Virol. 75, 11284–11291.
Reynolds, P. N., Dmitriev, I. and Curiel, D. T. (1999)Gene Ther. 6, 1336–1339.
Smith, T. A., Marshall-Neff, J., Idamakanti, N., Rolence, M. L., Kylefjord, H., Mulgrew, K., Theurer, M., Dinges, L., Kaleko, M. and Stevenson, S. C. (2002)Mol. Ther. 5, S208.
Halbert, C. L., Allen, J. M. and Miller, A. D. (2001)J. Virol. 75, 6615–6624.
Kaludov, N., Brown, K. E., Walters, R. W., Zabner, J. and Chiorini, J. A. (2001)J. Virol.75,6884–6893.
Hildinger, M., Auricchio, A., Gao, G., Wang, L., Chirmule, N. and Wilson, J. M. (2001)J. Virol. 75, 6199–6203.
Auricchio, A., Kobinger, G., Anand, V., Hildinger, M., O’Connor, E., Maguire, A. M.,Wilson, J. M. and Bennett, J. (2001)Hum. Mol. Gen. 10, 3075–3081.
Davidson, B. L., Stein, C. S., Heth, J. A., Martins, I., Kotin, R. M., Derksen, T. A., Zabner, J., Ghodis, A. and Chiorini, J. A. (2000) Proc. Nat. Acad. Sci. U.S.A. 97, 3428–3432.
Yan, Z., Zak, R., Luxton, G. W. G., Ritchie, T. C., Bantel-Schaal, U. and Engelhardt, J.F. (2002)J. Virol. 76, 2043–2053.
Gao, G.-P., Alvira, M. R., Calcedo, R., Johnston, J. and Wilson, J. M. (2002) Proc. Nat. Acad. Sci. U.S.A. 99, 11854–11859.
Summerford, C. and Samulski, R. J. (1998)J. Virol. 72, 1438–1445.
Qing, K., Mah, C., Hansen, J., Zhou, S., Dwarki, V. and Srivastava, A. (1999)Nature Med. 5, 71–77.
Summerford, C., Bartlett, J. S. and Samulski, R.-J. (1999)Nat. Med. 5, 78–82.
Passini, M. A., and Wolfe, J. H. (2001)J. Virol. 75, 12382–12392.
Kessler, P. D., Podsakoff, G. M., Chen, X., McQuiston, S. A., Colosi, P. C., Matelis, L. A., Kurtzman, G. J. and Byrne, B. J. (1996) Proc. Nat. Acad. Sci. U.S.A. 93, 14082–14087.
Koeberl, D. D., Alexander, I. E., Halbert, C. L., Russell, D. W. and Miller, A. D. (1997) Proc. Nat. Acad. Sci. U.S.A. 94, 1426–1431.
Ali, R. R., Reichel, M. B., Thrasher, A. J., Levinsky, R. J., Kinnon, C., Kanuga, N., Hunt,D. M. and Bhattacharya, S. S. (1996)Hum. Mol. Gen. 5, 591–594.
Fisher, K. J., Jooss, K., Alston, J., Yang, Y., Ehlen Haecker, S., High, K., Pathak, R.,Raper, S. E. and Wilson, J. M. (1997)Nature Med. 3, 306–312.
McCown, T. J., Xiao, X., Li, J., Breese, G. R. and Samulski, R. J. (1996)Brain Res. 713,99–107.
Duan, D., Yue, Y., Yan, Z. and Engelhardt, J. F. (2000)J. Clin. Invest. 105, 1573–1587.
Hansen, J., Qing, K., Kwon, H.-J., Mah, C. and Srivastava, A. (2000)J. Virol. 74, 992–996.
Hansen, J., Qing, K. and Srivastava, A. (2001)J. Virol. 75, 4080–4090.
Bartlett, J. S., Kleinschmidt, J., Boucher, R. C. and Samulski, R. J. (1999)Nature Biotechnol. 17, 181–186.
Ried, M. U., Girod, A., Leike, K., Buning, H. and Hallek, M. (2002)J. Virol. 76, 4559–4566.
Girod, A., Ried, M., Wobus, C., Lahm, H., Leike, K., Kleinschmidt, J., Deleage, G. And Hallek, M. (1999)Nature Med. 5, 1052–1056.
Grifman, M., Trepel, M., Speece, P., Gilbert, L. B., Arap, W., Pasqualini, R. And Weitzman, M. D. (2001)Mol. Ther. 3, 964–975.
Shi, W., Arnold, G. S. and Bartlett, J. S. (2001)Hum. Gene Ther. 12, 1697–1711.
Yang, Q. C., Mamounas, M., Yu, G., Kennedy, S., Leaker, B., Merson, J., WongStaal, F.,Yu, M. and Barber, J. R. (1998)Hum. Gene Ther. 9, 1929–1937.
Xie, Q., Bu, W., Bhatia, S., Hare, J., Somasundaram, T., Azzi, A. and Chapman, M. S.(2002) Proc. Nat. Acad. Sci. U.S.A. 99, 10405–10410.
Tsao, J., Chapman, M. S., Agbandje, M., Keller, W., Smith, K., Wu, H., Luo, M., Smith,T. J., Rossmann, M. G. and Compans, R. W. (1991)Science 251, 1456–1464.
Wistuba, A., Kern, A., Weger, S., Grmm, D. and Kleinschmidt, J. A. (1997)J. Virol. 71, 1929–1937.
Aumailley, M., Gerl, M., Sonnenberg, A., Deutzmann, R. and Timpl, R. (1990)FEBS Letts. 262, 82–86.
Wistuba, A., Weger, S., Kern, A. and Kleinschmidt, J. (1995)J. Virol. 69, 5311–5319.
Bayer, N., Schober, D., Prchla, E., Murphy, R. F., Blaas, D. and Fuchs, R. (1998)J.Virol. 72, 9645–9655.
Douar, A.-M., Poulard, K., Stockholm, D. and Danos, O. (2001)J. Virol. 75, 1824–1833.
Wilkinson, G. W. G. and Akrigg, A. (1992)Nucl. Acids Res. 20, 2233–2239.
Boshart, M., Weber, F., Jahn, G., Dorsch-Häsler, K., Fleckenstein, B. and Schaffner, W.(1985)Cell 41, 521–530.
Gorman, C. M., Merlino, G. T., Willingham, M. C., Pastan, I. and Howard, B. H. (1982) Proc. Nat. Acad. Sci. U.S.A. 79, 6777–6781.
Shi, Q., Wang, Y. and Worton, R. (1997)Hum. Gene Ther. 8, 403–410.
Addison, C. L., Hitt, M., Kunsken, D. and Graham, F. L. (1997)J. Gen. Virol. 78, 1653–1661.
Weiler-Guettler, H., Aird, W. C., Husain, M., Rayburn, H. and Rosenberg, R. D. (1996)Circ. Res. 78, 180–187.
Aird, W. C., Jahroudi, N., Weiler-Guettler, H., Rayburn, H. B. and Rosenberg, R. D. (1995) Proc. Nat. Acad. Sci. U.S.A. 92, 4567–4571.
Schlaeger, T. M., Bartunkova, S., Lawitts, J. A., Teichmann, G., Risau, W., Deutsch, U.and Sato, T. N. (1997)Proc. Nat. Acad. Sci. U.S.A. 94, 3058–3063.
Neish, A. S., Williams, A. J., Palmer, H. J., Whitley, M. Z. and Collins, T. (1992)J. Exp.Med. 176, 1583–1593.
Cybulsky, M. I. and Gimbrone, M. A. J. (1991)Science 251, 788–91.
Li, H., Cybulsky, M. I., Gimbrone, M. A. J. and Libby, P. (1993)Arterio. Thromb. Vasc.Biol. 13, 197–204.
de Fourgerolles, A.R., Stacker, S.A., Schwarting, R. and Springer, T.A. (1991)J. Exp. Med. 174, 253–267.
Cowan, P. J., Shinkel, T. A., Witwort, E. J., Barlow, H., Pearse, M. J. and D’Apice, A. J.F. (1996)Transplantation 62, 155–160.
Cowan, P. J., Tsang, D., Pedic, C. M., Abbott, L. R., Shinkel, T. A., D’Apice, A. J. F. And Pearse, M. J. (1998)J. Biol. Chem. 273, 11737–11744.
Velasco, B., Ramirez, J. R., Relloso, M., Li, C., Kumar, S., Lopez-Bote, J. P., Perez-Barriocanal, F., Lopez-Novoa, J. M., Cowan, P. J., D’Apice, A. J. F. and Bernabeu, C. (2001)Gene Ther. 8, 897–904.
Marietta, M. A. (1994)Cell 78, 927–930.
Griffith, O. W. and Stuehr, D. J. (1995)Annu. Rev. Physiol. 57, 707–736.
Marsden, P. A., Schappert, K. T., Chen, H. S., Flowers, M., Sundell, C. L., Wilcox, J.,Lamas, S. and Michel, T. (1992)FEBS Letts. 307, 287–293.
Marsden, P. A., Heng, H. H. Q., Scherer, S. W., Stewart, R. J., Hall, A. V., Shi, X.-M.,Tsui, L.-C. and Schappert, K. T. (1993)J. Biol. Chem. 268, 17478–17488.
Lamas, S., Marsden, P. A., Li, G. K., Tempst, P. and Michel, T. (1992) Proc. Nat. Acad.Sci. U.S.A. 89, 6348–6352.
Nishida, K., Harrison, D. G., Navas, J. P., Fisher, A. A., Dockery, S. P., Uematsu, M., Nerem, R. M., Alexander, R. W. and Murphy, T. J. (1992)J. Clin. Invest. 90, 2092–2096.
Piovella, F., Nialli, G., Malamani, G. D., Majolino, I., Frassoni, F., Sitar, G. M., Ruggeri,A., Dell’Orbo, C. and Ascari, E. (1977)Brit. J. Haematol. 39, 209–213.
Ferriera, V., Assouline, Z., Schwachtgen, J.-L., Bahnak, B. R., Meyer, D. and Kerbiriou-Nabias, D. (1993)Biochem. J. 293, 641–646.
Mancuso, D. J., Tuley, E. A., Westfield, L. A., Worall, N. K., Shelton-Inloes, B. B., Sorace, J. M., Alevy, Y. G. and Sadler, J. E. (1989)J. Biol. Chem. 264, 19514–19527.
Bonthron, D. and Orkin, S. H. (1988)Eur. J. Biochem. 171, 51–57.
Collins, C. J., Underdahl, J. P., Levene, R. B., Rayera, C. P., Morin, M. J., Dombalagian, M. J., Ricca, G., Livingston, D. M. and Lynch, D. C. (1987) Proc. Nat. Acad. Sci. U.S.A. 84,4393–4397.
Jahroudi, N. and Lynch, D. C. (1994)Mol. Cell. Biol. 14, 999–1008.
Ozaki, K., Yoshida, T., Ide, H., Saito, I., Ikeda, Y., Sugimura, T. and Masaaki, T. (1996)Hum. Gene Ther. 7, 1483–1490.
Aird, W. C., Edelberg, J. M., Weiler-Guettler, H., Simmons, W. W., Smith, T. W. and Rosenberg, R. D. (1997)J. Cell Biol. 138, 1117–124.
Jahroudi, N., Ardekani, A. M. and Greenberger, J. S. (1996)Blood 88, 3801–3814.
De Vries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N. and Williams, L. T. (1992)Science 255, 989–991.
Peters, K. G., De Vries, C. and Williams, L. T. (1993) Proc. Nat. Acad. Sci. U.S.A. 90, 8915–8919.
Morishata, K., Johnson, D. E. and Williams, L. T. (1995)J. Biol. Chem. 270, 27948–27953.
Wakija, K., Begue, A., Stehelin, D. and Shibuya, M. (1996)J. Biol. Chem. 271, 30823–30828.
Gerber, H.-P., Condorelli, F., Park, J. and Ferrara, N. (1997)J. Biol. Chem. 272, 23659–23667.
Chen, Y.S., Hackett, S. F., Schoenfeld, C.-L., Vinores, M. A., Vinores, S. A. and Campochiaro, P. A. (1997)Brit. J. Opthalmol. 81, 919–926.
Barleon, B., Sozzani, S., Zhou, D., Weich, H. A., Mantovani, A. and Marme, D. (1996)Blood 87,3336–3343.
Wang, H. and Keiser, J. A. (1998)Circ. Res. 83, 832–840.
Lindner, V. and Reidy, M. A. (1996) Arterio. Thromb. Vasc. Biol. 16, 1399–1405.
Bauerschmitz, G. J., Nettelbeck, D. M., Kanerva, A., Baker, A. H., Hemminki, A., Reynolds, P. N. and Curiel, D. T. (2002)Cancer Res. 62, 1271–1274.
Mimuro, J., Muramatsu, S., Hakamada, Y., Mori, K., Kikuchi, J., Urabe, M., Madoiwa, S., Ozawa, K. and Sakata, Y. (2001)Gene Ther. 8, 1690–1697.
Prentice, H., Bishopric, N. H., Hicks, M. N., Discher, D. J., Wu, X., Wylie, A. A. and Webster, K. A. (1997)Cardio. Res. 35, 567–574.
Aikawa, R., Huggins, G. S. and Snyder, R. O. (2002)J. Biol. Chem. 277, 18979–18985.
Su, H., Arakawa-Hoyt, J. and Kan, Y. W. (2002) Proc. Nat. Acad. Sci. U.S.A. 99 (14), 9480–9485.
Griscelli, F., Gilardi-Hebenstreit, P., Hanania, N., Franz, W.-M., Opolon, P., Perricaudet, M. and Ragout, T. (1998) Hum. Gene Ther. 9, 1919–1928.
Phillips, M. I., Tang, Y., Schmidt-Ott, K., Qian, K. and Kagiyama, S. (2002)Hypertension 39, 651–655.
Moessler, H., Mericskay, M., Li, Z., Nagl, S., Paulin, D. and Small, J. V. (1996)Development 122, 2415–2425.
Ribault, S., Neuville, P., Mechine-Neuville, A., Auge, F., Parlakian, A., Gabbiani, G,Paulin, D. and Calenda, V. (2001)Circ. Res. 88, 468–475.
Keogh, M.-C., Chen, D., Schmitt, J. F., Kakkar, V. V. and Lemoine, N. R. (1999)Gene Ther. 6, 616–628.
Wills, K. N., Mano, T., Avanzini, J. B., Nguyen, T., Antelman, D., Gregory, R. J., Smith, R. C. and Walsh, K. (2001)Gene Ther. 8, 1847–1854.
Li, X., Eastman, E. M., Schwartz, R. J. and Draghia-Akli, R. (1999)Nature Biotechnol.17, 241–245.
Edelman, G. M., Meech, R., and Jones, F. S. (2000)Proc. Nat. Acad. Sci.U.S.A. 97, 3038–3043.
Gossen, M. and Bujard, H. (1992) Proc. Nat. Acad. Sci. U.S.A. 89, 5547–5551.
Gossen, M., Freundlieb, S., Bender, G., Muller, G., Hillen, W. and Bujard, H. (1995)Science 268, 1766–1769.
Ghersa, P., Pescini Gobert, R., Sattonnet-Roche, P., Richards, C. A., Merlo Pic.And Hooft van Huijduijnen, R. (1998)Gene Ther. 5, 1213–1220.
Rubinchik, S., Wang, D., Yu, H., Fan, F., Luo, M., Norris, J. S. and Dong, J.-Y. (2001)Mol. Ther. 4, 416–426.
Smith-Arica, J. R., Morelli, A. E., Larregina, A. T., Smith, J., Lowenstein, P. R. And Castro, M. G. (2000)Mol. Ther. 2, 579–587.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Nicklin, S.A., Baker, A.H. (2003). Development of Targeted Viral Vectors for Cardiovascular Gene Therapy. In: Setlow, J.K. (eds) Genetic Engineering. Genetic Engineering: Principles and Methods, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0073-5_2
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0073-5_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4911-2
Online ISBN: 978-1-4615-0073-5
eBook Packages: Springer Book Archive