Abstract
The Briard dog is affected by an autosomal recessively inherited retinal disease with severe, early-onset visual impairment or blindness. The external structures of the eye appear normal but most affected dogs have a rapid, quivering nystagmus and a wider resting pupillary diameter than normal dogs (Narfstrom et al., 1994). Electroretinography (ERG) is diagnostic in puppies, with non-recordable dark adapted responses and either non-recordable or low amplitude photopic ERG responses. The internal structures of the eye are normal appearing up to several years of age. In older animals changes such as attenuation of retinal vasculature and paling of the tapetal fundus are most often present. In 3-4 year-old affected dogs, yellow specks or spots may also be observed, mainly in the central parts of the fundus, that increase and spread peripherally with age.
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Narfström, K., Bragadóttir, R., Redmond, T.M., Rakoczy, P.E., van Veen, T., Bruun, A. (2003). Functional and Structural Evaluation after AAV.RPE65 Gene Transfer in the Canine Model of Leber’s Congenital Amaurosis. In: LaVail, M.M., Hollyfield, J.G., Anderson, R.E. (eds) Retinal Degenerations. Advances in Experimental Medicine and Biology, vol 533. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0067-4_54
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DOI: https://doi.org/10.1007/978-1-4615-0067-4_54
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