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Malaria Pigment

  • Living reference work entry
  • First Online:
Encyclopedia of Malaria

Synonyms

4-Hydroxynonenal (HNE); Blood–brain barrier (BBB); Dendritic cell (DC); Endothelial cell (EC); Erythroblastic island (EI); Erythrocyte, red blood cell (RBC); Fatty acids (FA); Fibrinogen (FG); Hemozoin (HZ); Hydroxyeicosatetraenoic acids (HETEs); Hydroxyoctadecadienoic acids (HODEs); Infected erythrocyte, infected RBC (iRBC); Malaria pigment; Monocyte chemotactic protein 1 (MCP-1); Natural HZ (nHZ); Oxidant radicals, radical oxidant species (ROS); Parasitized erythrocyte, parasitized red blood cell (pRBC); Plasmodium falciparum, P. falciparum, falciparum (Pf); Polyunsaturated fatty acids (PUFA); Synthetic hemozoin (sHZ); Toll-like receptor (TLR); White blood cells (WBC); β-hematin

Definition

Hemozoin is a stable insoluble crystalline dimer of ferriprotoporphyrin IX formed from indigestible ferric heme after hemoglobin digestion in the parasite food vacuole. After schizogony it is avidly phagocytosed in its native form (which also contains saturated and unsaturated lipids and...

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Authors and Affiliations

  1. Department of Oncology, University of Torino, Via Santena 5 bis, Torino, 10126, Italy

    Paolo Arese, Evelin Schwarzer & Oleksii Skorokhod

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  1. Paolo Arese
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  2. Evelin Schwarzer
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    Marcel Hommel

  2. Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany

    Peter G. Kremsner

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Arese, P., Schwarzer, E., Skorokhod, O. (2014). Malaria Pigment. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_83-1

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