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Adjunctive Therapies for Malaria

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  • First Online:
Encyclopedia of Malaria

Synonyms

Adjunctive; Cerebral; Intervention; Malaria; Plasmodium falciparum ; Severe; Treatment

Definition of Adjunctive Therapies

Adjunctive therapies are treatments used in conjunction with a primary treatment (e.g., antimicrobial therapy) to increase the possibility of successful clinical outcome of a condition or disease state. In some instances, such as in malaria, adjunctive therapies are introduced to treat the complications of the disease (e.g., endothelial cell activation, microvascular injury and obstruction, and multiorgan dysfunction) rather than the causative agent (e.g., Plasmodium parasites) with the aim of reducing the risk of death and/or disability associated with infection.

Severe Malaria: A Role for Adjunctive Therapies?

The majority of Plasmodium-infected individuals with symptomatic malaria can be effectively managed with prompt diagnosis and appropriate oral antimalarial treatment. However, a small proportion of individuals may present with, or progress to,...

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Authors and Affiliations

  1. Sandra A. Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, M5G 1L7, Toronto, Canada

    Sarah J. Higgins, Robyn E. Elphinstone & Kevin C. Kain

  2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    Sarah J. Higgins, Robyn E. Elphinstone & Kevin C. Kain

  3. Department of Medicine, University of Toronto, Toronto, M5G 2C4, Canada

    Kevin C. Kain

  4. Tropical Disease Unit, Toronto General Hospital, M5G 2C4, Toronto, Canada

    Kevin C. Kain

Authors
  1. Sarah J. Higgins
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  2. Robyn E. Elphinstone
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  3. Kevin C. Kain
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Correspondence to Kevin C. Kain .

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Editors and Affiliations

  1. Heswall, United Kingdom

    Marcel Hommel

  2. Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany

    Peter G. Kremsner

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Higgins, S.J., Elphinstone, R.E., Kain, K.C. (2014). Adjunctive Therapies for Malaria. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_123-1

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