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p75NTR Processing and Signaling: Functional Role

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Handbook of Neurotoxicity

Abstract

The p75 neurotrophin receptor (p75NTR) was the first neurotrophin receptor to be identified and, more than two decades after, significant advances have been made in understanding its biological actions. p75NTR belongs to the tumor necrosis factor receptor superfamily (TNFRS) and is particularly important during developmental neural cell death and under injury conditions in the adulthood. However, recent studies shed new light into the functions of p75NTR in the nervous system. p75NTR either acting autonomously or as part of a complex with other co-receptors regulates neuronal survival and differentiation, cell cycle and proliferation, axonal outgrowth, and synaptic plasticity. Here, we will review the main findings of the last two decades as well as new findings that reveal additional and unexpected roles for p75NTR.

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Acknowledgments

The work in the authors’ laboratory is supported by FEDER through Programa Operacional Factores de Competitividade (COMPETE) and by national funds through Fundação para a Ciência e a Tecnologia (FCT) through Grants PTDC/SAU-NEU/104100/2008, EXPL/NEU-NMC/0541/2012, PTDC/SAU-NEU/104297/2008, PTDC/SAU-NMC/120144/2010, PEst-C/SAU/LA0001/2013-2014, and by Marie Curie Actions, International Reintegration Grant, 7th Framework Programme, EU.

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  1. Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal

    Ramiro D. Almeida

  2. Center for Neuroscience and Cell Biology (CNC) and Department of Life Sciences, University of Coimbra, Largo Marquês de Pombal, 3004-517, Coimbra, Portugal

    Carlos B. Duarte

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  1. Ramiro D. Almeida
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Correspondence to Carlos B. Duarte .

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  1. Department of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee, USA

    Richard M. Kostrzewa

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Almeida, R.D., Duarte, C.B. (2014). p75NTR Processing and Signaling: Functional Role. In: Kostrzewa, R. (eds) Handbook of Neurotoxicity. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5836-4_25

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