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The FtsK Family of DNA Pumps

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DNA Helicases and DNA Motor Proteins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 767))

Abstract

Interest for proteins of the FtsK family initially arose from their implication in many primordial processes in which DNA needs to be transported from one cell compartment to another in eubacteria. In the first section of this chapter, we address a list of the cellular functions of the different members of the FtsK family that have been so far studied. Soon after their discovery, interest for the FstK proteins spread because of their unique biochemical properties: most DNA transport systems rely on the assembly of complex multicomponent machines. In contrast, six FtsK proteins are sufficient to assemble into a fast and powerful DNA pump; the pump transports closed circular double stranded DNA molecules without any covalent-bond breakage nor topological alteration; transport is oriented despite the intrinsic symmetrical nature of the double stranded DNA helix and can occur across cell membranes. The different activities required for the oriented transport of DNA across cell compartments are achieved by three separate modules within the FtsK proteins: a DNA translocation module, an orientation module and an anchoring module. In the second part of this chapter, we review the structural and biochemical properties of these different modules.

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Acknowledgements

We would like to acknowledge financial support from the Agence Nationale pour la Recherche [ANR-09-BLAN-0258] and from the European Research Council under the European Community’s Seventh Framework Programme [FP7/2007-2013 Grant Agreement no. 281590].

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  1. Centre de Génétique Moléculaire, CNRS, Gif sur Yvette, Cedex, France

    Gaëlle Demarre, Elisa Galli & François-Xavier Barre

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  1. Gaëlle Demarre
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  2. Elisa Galli
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  3. François-Xavier Barre
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Correspondence to François-Xavier Barre .

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  1. , Department of Biochemistry, University of Iowa Carver College of Med, Newton Rd. 51, Iowa City, 52242, Iowa, USA

    Maria Spies

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Demarre, G., Galli, E., Barre, FX. (2013). The FtsK Family of DNA Pumps. In: Spies, M. (eds) DNA Helicases and DNA Motor Proteins. Advances in Experimental Medicine and Biology, vol 767. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5037-5_12

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