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Introduction to the Microdialysis Technology

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Microdialysis in Drug Development

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 4))

Abstract

Microdialysis (μD) has been established as a reliable in vivo tool to measure interstitial drug concentrations quasi online in virtually every given tissue and organ in animals and humans. Following its first description in the 1970s μD has been further developed and employed as a research and drug development tool in >14,000 PubMed publications. The rationale for the application of μD in Pharma R&D is based on the presence of blood to tissue barriers which hamper drug penetration to target sites. A clear understanding of target site pharmacokinetics (PK), as provided by μD and complementary techniques is a prerequisite for understanding drug action in vivo.

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  1. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

    Markus Müller

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  1. Allgemeines Krankenhaus, Department of Clinical Pharmacology, Medical University Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria

    Markus Müller

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Müller, M. (2013). Introduction to the Microdialysis Technology. In: Müller, M. (eds) Microdialysis in Drug Development. AAPS Advances in the Pharmaceutical Sciences Series, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4815-0_1

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