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Antibody Polyspecificity

What Does It Matter?

  • Chapter
Naturally Occurring Antibodies (NAbs)

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 750))

Abstract

Polyspecificity (polyreactivity) is currently considered an intrinsic property of a subset of antibodies, primarily of naturally occurring autoantibodies. Polyspecificity is no longer viewed as a biologically irrelevant stickiness. Furthermore, the capacity to bind defined sets of unrelated antigens finds its structural explanation. What is most intriguing, the elucidation of the role of polyspecificity may promote a better understanding of specific recognition as a function of the entire immune system. The early events of immune recognition depend on polyspecific binding. Thus, the completeness of the naïve repertoires of antigen receptors is ensured. The process of immunologically-relevant antigen recognition that is initiated goes beyond simple molecular interaction with the antigenic determinants. It involves cellular cooperation and culminates in antibody response maturation. Recent findings also pave the way for the clinical application of posttranslationally induced polyspecificity.

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Authors and Affiliations

  1. INSERM UMRS 872, Paris, France

    Jordan D. Dimitrov

  2. Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria

    Anastas D. Pashov & Tchavdar L. Vassilev

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  1. Jordan D. Dimitrov
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  2. Anastas D. Pashov
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  3. Tchavdar L. Vassilev
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Correspondence to Tchavdar L. Vassilev .

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Editors and Affiliations

  1. Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Hönggerberg, Zurich, Switzerland

    Hans U. Lutz

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Dimitrov, J.D., Pashov, A.D., Vassilev, T.L. (2012). Antibody Polyspecificity. In: Lutz, H.U. (eds) Naturally Occurring Antibodies (NAbs). Advances in Experimental Medicine and Biology, vol 750. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3461-0_16

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