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The Role of Reactive Oxygen Species in Ocular Malignancy

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 801))

Abstract

Increased production of reactive oxygen species (ROS) is an attribute of malignant cells and is linked to the development of many of the characteristics considered “hallmarks of cancer (Hanahan and Weinberg, Cell 144(5), 2011, 646–674).” Among these are sustained proliferative signaling, induction of new vascular growth, promotion of invasion, and metastatic potential. Maintaining the balance between the beneficial biological functions of ROS and the dysregulation seen in human disease such as cancer, presents a daunting conundrum in the future of oncology research. ROS involvement is pervasive throughout the process of tumorigenesis and subsequent cancer growth, yet the response to both pro- and antioxidant based therapy is varied. We will review the ROS species in the pathogenesis of primary ocular malignancy with consideration of potential targets for therapeutic intervention.

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Author information

Authors and Affiliations

  1. Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, USA

    Kathryn E. Klump & James F. McGinnis

  2. Dean A. McGee Eye Institute, 608 Stanton L. Young Boulevard, Pavilion B, L047, 73104, Oklahoma City, OK, USA

    Kathryn E. Klump

  3. Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, USA

    James F. McGinnis

  4. Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, USA

    James F. McGinnis

Authors
  1. Kathryn E. Klump
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  2. James F. McGinnis
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Corresponding author

Correspondence to Kathryn E. Klump .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, University of Florida, Gainesville, Florida, USA

    John D. Ash

  2. University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  3. Cole Eye Institute at the Cleveland Clin Division of Ophthalmology, Cleveland, Ohio, USA

    Joe G. Hollyfield

  4. Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  5. Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Matthew M. LaVail

  6. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

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Klump, K., McGinnis, J. (2014). The Role of Reactive Oxygen Species in Ocular Malignancy. In: Ash, J., Grimm, C., Hollyfield, J., Anderson, R., LaVail, M., Bowes Rickman, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 801. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3209-8_82

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  • DOI: https://doi.org/10.1007/978-1-4614-3209-8_82

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-3208-1

  • Online ISBN: 978-1-4614-3209-8

  • eBook Packages: MedicineMedicine (R0)

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