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Immunotherapeutic Approach with Oligodeoxynucleotides Containing CpG Motifs (CpG-ODN) in Malignant Glioma

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Glioma

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 746))

Abstract

Bacterial DNA and synthetic oligodeoxynucleotides containing CpG motifs (CpG-ODNs) are strong activators of both innate and specific immunity, driving the immune response towards the Th1 phenotype. In cancer patients, CpG-ODNs can be used to activate the innate immunity and trigger a tumor-specific immune response. Several clinical trials are on-going worldwide in various cancers. In this chapter, we will focus on the potential applications of CpG-ODNs in glioma. So far, CpG-ODN has mainly been used by intratumoral injections. Indeed, human gliomas display a locally invasive pattern of growth and rarely metastasize, making local treatment clinically relevant.

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  1. Service de Neurologie, Hôpital Avicenne, Bobigny, France

    Renata Ursu & Antoine F. Carpentier

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  1. Renata Ursu
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  2. Antoine F. Carpentier
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Correspondence to Antoine F. Carpentier .

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  1. Kyoto Prefectural University of Medicine, Kyoto, Japan

    Ryuya Yamanaka MD, PhD

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Ursu, R., Carpentier, A.F. (2012). Immunotherapeutic Approach with Oligodeoxynucleotides Containing CpG Motifs (CpG-ODN) in Malignant Glioma. In: Yamanaka, R. (eds) Glioma. Advances in Experimental Medicine and Biology, vol 746. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3146-6_8

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