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Notch Signaling in Lung Development and Disease

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Notch Signaling in Embryology and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 727))

Abstract

Notch signaling plays an essential role in development and homeostasis of multiple organs including the lung. Dysregulation of Notch signaling has been implicated in various lung diseases including lung cancer. Here we review functions of Notch signaling in coordinating events during lung development, such as early proximodistal fate generation and branching, airway epithelial cell fate specification, alveogenesis and pulmonary vascular development. We also discuss roles of Notch in chronic obstructive pulmonary disease, progressive pulmonary fibrosis, pulmonary arterial hypertension, asthma and lung cancer.

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Author information

Authors and Affiliations

  1. Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

    Keli Xu & Sean E. Egan

  2. Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada

    Nadeem Moghal

  3. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

    Sean E. Egan

  4. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    Nadeem Moghal

Authors
  1. Keli Xu
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  2. Nadeem Moghal
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  3. Sean E. Egan
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Corresponding author

Correspondence to Sean E. Egan .

Editor information

Editors and Affiliations

  1. Department of Dermatology, The Saarland University Hospital, Homburg, Germany

    Jörg Reichrath

  2. Department of Internal Medicine I, The Saarland University Hospital, Homburg, Germany

    Sandra Reichrath

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© 2012 Landes Bioscience and Springer Science+Business Media

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Xu, K., Moghal, N., Egan, S.E. (2012). Notch Signaling in Lung Development and Disease. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 727. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0899-4_7

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