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Overview of Controlled Release Mechanisms

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Fundamentals and Applications of Controlled Release Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Controlled release systems have been developed to improve the temporal and spatial presentation of drug in the body, to protect drug from physiological degradation or elimination, to improve patient compliance, and to enhance quality control in manufacturing of drug products. When designing controlled-release systems, it is important to identify and understand particular mechanisms involved in the release process. Often, more than one mechanism is involved at a given time or different mechanisms may dominate at different stages of the drug delivery process. This chapter begins with several vignettes, each highlighting a mode of controlled drug delivery and identifying associated mechanisms. An introductory description of several of the mechanisms follows. Details regarding these mechanisms are provided in subsequent chapters.

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Author information

Authors and Affiliations

  1. Departments of Pharmaceutics and Biomedical Engineering, University of Minnesota, Minneapolis, MN, 55419, USA

    Ronald A. Siegel

  2. Department of Pharmaceutics WDH 9-177, University of Minnesota, 308 Harvard St. S.E., Minneapolis, MN, 55455, USA

    Ronald A. Siegel

  3. School of Pharmacy, Griffith University, Southport, QLD, 4222, Australia

    Michael J. Rathbone

Authors
  1. Ronald A. Siegel
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  2. Michael J. Rathbone
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Corresponding author

Correspondence to Ronald A. Siegel .

Editor information

Editors and Affiliations

  1. Rue Maurice Schumann 3, Phalempin, 59133, France

    Juergen Siepmann

  2. , Department of Pharmaceutics, University of Minnesota, Harvard Street SE 308, Minneapolis, 55455, Minnesota, USA

    Ronald A. Siegel

  3. , School of Pharmacy, Griffith University, Parklands Drive 1, Southport, 4215, Queensland, Australia

    Michael J. Rathbone

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© 2012 Springer US

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Siegel, R.A., Rathbone, M.J. (2012). Overview of Controlled Release Mechanisms. In: Siepmann, J., Siegel, R., Rathbone, M. (eds) Fundamentals and Applications of Controlled Release Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0881-9_2

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