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Receptor Mediated Delivery Systems for Cancer Therapeutics

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Fundamentals and Applications of Controlled Release Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Directing anticancer agents specifically to tumors and/or cancer cells by targeting specific extracellular receptors fulfills the following three most important tasks: (1) preventing or at least substantially limiting adverse side effects on healthy tissues; (2) enhancing drug internalization by cancer cells; and (3) overcoming (at least in part) resistance mechanisms that are based on the active efflux of exogenous drugs from cancer cells. This review is focused on the last decade of accomplishments in the field of cancer-targeted drug delivery and describes different approaches to receptor-targeted delivery of anticancer agents. Mechanisms of receptor mediated endocytosis, targeting folate, carbohydrate (lactose, galactosamine, ascorbic acid, hyaluronic acid), peptide, and protein (somatostatin, growth factor, tissue factor, integrin, transferrin, vitamin, and luteinizing hormone-releasing hormone) receptors are discussed.

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Authors and Affiliations

  1. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Rd, Piscataway, NJ, 08854-8020, USA

    Tamara Minko

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  1. Tamara Minko
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Correspondence to Tamara Minko .

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Editors and Affiliations

  1. Rue Maurice Schumann 3, Phalempin, 59133, France

    Juergen Siepmann

  2. , Department of Pharmaceutics, University of Minnesota, Harvard Street SE 308, Minneapolis, 55455, Minnesota, USA

    Ronald A. Siegel

  3. , School of Pharmacy, Griffith University, Parklands Drive 1, Southport, 4215, Queensland, Australia

    Michael J. Rathbone

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Minko, T. (2012). Receptor Mediated Delivery Systems for Cancer Therapeutics. In: Siepmann, J., Siegel, R., Rathbone, M. (eds) Fundamentals and Applications of Controlled Release Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0881-9_12

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