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Long Noncoding RNA and Epigenomics

  • Chapter
RNA Infrastructure and Networks

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 722))

Abstract

Accumulating evidence over the last decade has presented us with the intriguing observation that the majority of eukaryotic genomes are pervasively transcribed to encode a complex network of small and long noncoding RNAs. Long noncoding RNAs are of particular interest, as they were once thought to be restricted to housekeeping functions and are now linked to a wide variety of biological functions related to physiology, embryology and development. Emerging evidence indicates that a subset of long noncoding RNAs mediate their biological functions by using chromatin as a substrate, to index the genetic information encoded in the genome. This chapter will discuss how noncoding RNAs and the processes underlying their transcription mediate transcriptional regulation, by epigenetically regulating the structure of chromatin in various biological contexts.

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Authors and Affiliations

  1. Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden

    Chandrasekhar Kanduri

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  1. Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand

    Lesley J. Collins

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Kanduri, C. (2011). Long Noncoding RNA and Epigenomics. In: Collins, L.J. (eds) RNA Infrastructure and Networks. Advances in Experimental Medicine and Biology, vol 722. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0332-6_11

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