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The Fine Structure of Slow-Wave Sleep Oscillations: from Single Neurons to Large Networks

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Sleep and Anesthesia

Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI,volume 15))

Abstract

This chapter reviews experiments, analyses and models of neuronal activity in the thalamus and cerebral cortex during wake and sleep states. The emphasis is on how the microscopic (units, intracellular) and macroscopic (LFPs, EEG) activity organizes within the different states. In a first part, the correspondence between electroencephalogram (EEG) oscillations and neuronal activity is reviewed. Two types of oscillations are then examined in more detail: spindle (7–14 Hz) and slow (0.1–4 Hz) oscillations. For each, experiments and models are contrasted. Implications of these experimental and modeling results onto the role of slow-wave sleep in consolidating memories are discussed.

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Notes

  1. 1.

    The absolute conductance is lower in activated states compared to Up-states, but both states are characterized by similar ratios between excitatory and inhibitory conductances (Rudolph et al. 2005).

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Acknowledgements

Research supported by CNRS, ANR (HR-CORTEX grant), the European Community (FET grants FACETS FP6-015879, BRAINSCALES FP7-269921) and the NIH (R01EY020765).

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Authors and Affiliations

  1. Unité de Neuroscience, Information et Complexité (UNIC), CNRS, 1 Avenue de la Terrasse (Bat. 33), 91190, Gif-sur-Yvette, France

    A. Destexhe

  2. Department of Neuroscience, University of Pennsylvania, Philadelphia, USA

    D. Contreras

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  1. A. Destexhe
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  2. D. Contreras
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Correspondence to A. Destexhe .

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  1. Equipe Cortex, INRIA CR Nancy, rue du Jardin Botanique 615, Villers-lès-Nancy CX, 54602, France

    Axel Hutt

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Destexhe, A., Contreras, D. (2011). The Fine Structure of Slow-Wave Sleep Oscillations: from Single Neurons to Large Networks. In: Hutt, A. (eds) Sleep and Anesthesia. Springer Series in Computational Neuroscience, vol 15. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0173-5_4

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