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Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds

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Current Topics in Innate Immunity II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 946))

Abstract

Microbes colonizing and/or infecting chronic wounds undoubtedly play a major and interactive role in impaired healing, especially in amplifying and perpetuating the host innate immune response. The development of molecular techniques to identify and quantify microbial organisms has revolutionized our view of the microbial world. These less-biased, high throughput methods greatly enable investigations regarding host–microbe interactions in the chronic wound environment. This review focuses on the mounting evidence implicating microbes and excessive inflammation in chronic wounds, as well as the challenges associated with understanding how microbes modulate wound healing and the innate immune response.

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Acknowledgements

The authors thank Heidi Kong and Sue Gardner for their underlying contributions, thoughtful discussions, and critical reading of the manuscript. The authors have no conflict of interest.

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Authors and Affiliations

  1. Epithelial Biology Section, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, 20892-4442, Bethesda, MD, USA

    Elizabeth A. Grice & Julia A. Segre

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  1. Elizabeth A. Grice
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  2. Julia A. Segre
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Correspondence to Julia A. Segre .

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Editors and Affiliations

  1. Department Of Pathology Laboratory Of, Medicine, University Of Pennsylvania, Johnson Pavilion 410, Philadelphia, 19104, Pennsylvania, USA

    John D. Lambris

  2. Health Sciences Center, University of Louisville, Louisville, 40292, Kentucky, USA

    George Hajishengallis

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Grice, E.A., Segre, J.A. (2012). Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds. In: Lambris, J., Hajishengallis, G. (eds) Current Topics in Innate Immunity II. Advances in Experimental Medicine and Biology, vol 946. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0106-3_4

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