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Gene Activation by 5-Azacytidine

  • Chapter
DNA Methylation

Part of the book series: Springer Series in Molecular Biology ((SSMOL))

Abstract

The nucleoside analog 5-azacytidine (5-aza-C) was first synthesized in Czechoslovakia in 1963 (Piskala and Sorm, 1964); it also has been isolated from streptoverticillium (Streptoverticillus ladakanus, Hanka et al. 1966; Bergy and Herr, 1966). 5-Aza-C differs from cytidine only by the inclusion of a nitrogen atom in the 5 position of the pyrimidine ring (Figure 9.1). It was originally developed for use as a cancer chemotherapeutic agent and is still-used in the treatment of certain types of acute myelogenous leukemia. However, recent interest in the drug has been directed toward its remarkable ability to induce the expression of repressed genes in eukaryotic cells and to act as an inhibitor of DNA methylation.

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Authors and Affiliations

  1. University of Southern California Comprehensive Cancer Center, 2025 Zonal Avenue, Los Angeles, California, 90033, USA

    Peter A. Jones

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Editors and Affiliations

  1. Department of Cellular Biology, The Hebrew University Hadassah Medical School, 91-010, Jerusalem, Israel

    Aharon Razin (Chairman) (Chairman)

  2. Department of Cellular Biochemistry, The Hebrew University Hadassah Medical School, 91-010, Jerusalem, Israel

    Howard Cedar

  3. Beckman Research Institute of the City of Hope, 91010, Duarte, California, USA

    Arthur D. Riggs

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Jones, P.A. (1984). Gene Activation by 5-Azacytidine. In: Razin, A., Cedar, H., Riggs, A.D. (eds) DNA Methylation. Springer Series in Molecular Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8519-6_9

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  • DOI: https://doi.org/10.1007/978-1-4613-8519-6_9

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