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Modeling Mechanical-Electrical Transduction in the Heart

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Cell Mechanics and Cellular Engineering

Abstract

The rate and rhythm of the heart is sensitive to mechanical deformation. As early as 1915, Bainbridge reported that distention of the atria produced an increase in heart rate (Bainbridge, 1915). Later studies showed that stretching alters action potential configuration (Dudel and Trautwein, 1954; Rosen et al. 1981; Dean and Lab, 1989; Lab, 1980; Taggart et al. 1992c; Taggart et al. 1992a; Taggart et al. 1992b; White et al. 1993), cause quiescent tissue to become spontaneously active and cause the generation of extra systoles (Hansen et al. 1990; Rajala et al. 1990; Stacy, Jr. et al. 1992; Sideris et al. 1990; Sideris et al. 1989; Hansen et al. 1991).

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Authors
  1. F. Sachs
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Editor information

Editors and Affiliations

  1. Orthopaedic Research Laboratory, Columbia University, 630 W. 168th Street, New York, NY, 10032, USA

    Van C. Mow

  2. Department of Aerospace Engineering, Mechanics and Engineering Science, University of Florida, Gainesville, FL, 32611, USA

    Roger Tran-Son-Tay

  3. Musculo-Skeletal Research Laboratory, Department of Orthopaedics, Health Science Center, State University of New York, Stony Brook, NY, 11794, USA

    Farshid Guilak

  4. Department of Mechanical Engineering and Material Sciences, Duke University, Durham, NC, 27708, USA

    Robert M. Hochmuth

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© 1994 Springer-Verlag New York, Inc.

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Sachs, F. (1994). Modeling Mechanical-Electrical Transduction in the Heart. In: Mow, V.C., Tran-Son-Tay, R., Guilak, F., Hochmuth, R.M. (eds) Cell Mechanics and Cellular Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8425-0_18

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  • DOI: https://doi.org/10.1007/978-1-4613-8425-0_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8427-4

  • Online ISBN: 978-1-4613-8425-0

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