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Ionic Mechanisms Governing the Control of Growth Hormone Secretion by Somatostatin

  • Conference paper
Growth Hormone II

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

Abstract

Readers are referred to a recent symposium (1) and reviews (2–4) for a comprehensive and broad introduction to somatostatin (SS) and its actions. This chapter will be restricted to the mechanisms (primarily ionic) by which SS inhibits growth hormone (GH) release. The abundant literature on the actions of SS on other cell types will not be discussed unless directly relevant to ionic mechanisms in somatotrophs. We will begin by summarizing the ionic mechanisms by which growth hormone releasing factor (GRF) stimulates the acute release of GH via cyclic AMP (cAMP) and cytosolic free Ca++ ([Ca++]i) as second messengers (Fig. 2.1). This is discussed in more detail elsewhere in this volume.

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Authors
  1. Jacob Kraicer
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  2. Stephen M. Sims
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Editor information

Editors and Affiliations

  1. Pediatric Endocrinology, All Children’s Hospital, St. Petersburg, FL, 33701, USA

    Barry B. Bercu M.D.  & Richard F. Walker Ph.D.  & 

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Kraicer, J., Sims, S.M. (1994). Ionic Mechanisms Governing the Control of Growth Hormone Secretion by Somatostatin. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone II. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8372-7_2

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  • DOI: https://doi.org/10.1007/978-1-4613-8372-7_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8374-1

  • Online ISBN: 978-1-4613-8372-7

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