Abstract
Testosterone and 5α-reduced androgens maintain spermatogenesis in hypophysectomized rats (1,2). A specific receptor protein for testosterone and dihydrotestosterone has been demonstrated in testis (3–6), however, the androgen target cells containing these receptors have not yet been identified. In the present study, we used an autoradiographic technique (7), which avoids translocation and diffusion artifacts during tissue preparation. Experiments were carried out to determine whether the accumulation of androgen can be localized to specific types of cells within the testis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Albert, A. The Mammalian Testis. In Sex and Internal Secretion, W.C. Young (Ed.), Vol. I, Williams and Wilkins Co., Baltimore, pp. 305–365, 1961.
Steinberger, E., and Steinberger, A. The Testis: Growth Versus Function. In Regulation of Organ and Tissue Growth, R.J. Goss (Ed.), Academic Press, New York, pp. 299–314, 1972.
Hansson, V., McLean, W.S., Smith, A.A., Tindall, D.J., Weddington, S.C., Nayfeh, S.N., French, F.S., and Ritzen, E.M., Steroids 23: 823–832, 1974.
McLean, W.S., Smith, A.A., Hansson, V., Naess, O., Nayfeh, S.N., and French, F.S., Mole. Cell. Endocr. (in press), 1975.
Smith, A.A., McLean, W.S., Hansson, V., Nayfeh, S.N., and French, F.S. Steroids 25: 569, 1975.
Mulder, E., Peters, M.J., deVries, J., and van der Molen, H.J., Mol. Cell. Endocr. 2: 171, 1975.
Stumpf, W.E., and Sar, M. Autoradiographic Techniques for Localizing Steroid Hormones. In Methods in Enzymology, O’Malley, B.W., and Hardman, J.G. (Eds.), Vol. 36, Academic Press, N.Y., pp. 135–156, 1975.
Stumpf, W.E., and Sar, M. Autoradiographic Localization of Estrogen, Androgen, Progestin and Glucocorticosteroid in “target tissues” and “non-target tissues.” In Receptors and Mechanism of Action of Steroid Hormones, Pasqualini, J. (Ed.), Marcel Dekker, N.Y., in press, 1975.
Stumpf, W.E. Endocrinology 85: 31–37, 1969.
Mulder, E., van Buerden-Lamers, W.M.O., DeBoer, W., Brinkman, A.O., and van der Molen, H.J. In Hormone Binding and Target Cell Activation in the Testis, Dufau, M., and Means, A. (Eds.), Plenum Press, p. 343, 1974.
Hovatta, O. Z. Zellforsch. 131: 299–308, 1972.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Plenum Press, New York
About this chapter
Cite this chapter
Sar, M. et al. (1975). Localization of Androgen Target Cells in the Rat Testis: Autoradiographic Studies. In: French, F.S., Hansson, V., Ritzen, E.M., Nayfeh, S.N. (eds) Hormonal Regulation of Spermatogenesis. Current topics in Molecular Endocrinology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4440-7_22
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4440-7_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4442-1
Online ISBN: 978-1-4613-4440-7
eBook Packages: Springer Book Archive