Abstract
Four-hundred and fourteen cases of human cancers in various clinical situations are reported. Randomized studies in advanced breast cancer and lung cancer, comparing combination chemotherapy with the same chemotherapy and weekly subcutaneous injections of Corynebacterium parvum, showed a significant superiority of the latter procedure in survival and resistance to bone-marrow depression and infections. Some uncontrolled studies showed an indication of synergism between C. parvum and BCG and a local effect of C. parvum injected intratumorally. Recent studies of C. parvum injected intravenously each day in a dose of 4 mg and without chemotherapy showed very promising and intriguing results in various disseminated cancers. Four good partial regressions were registered out of 12 patients. Problems relative to immune status and optimal conditions for nonspecific immune stimulation are discussed.
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References
Dimitrov, N. V. (1975). In this volume.
Halpern, B. N., Prévot, A. R., Biozzi, G., Stiffel, C., Mouton, D., Morard, J. C., Bouthillier, Y., and Decreusefond, C. (1964). Stimulation de l’activité phagocytaire du système réticuloendothélial provoquée par Corynebacterium parvum. J. Reticuloendothel. Soc. 1: 77–96.
Halpern, B. N., Biozzi, G., Stiffel, C., and Mouton, D. (1966). Inhibition of tumor growth by administration of killed Corynebacterium parvum. Nature (Loud.) 212: 853–854.
Israel, L. (1973). Preliminary results of non-specific immunotherapy for lung cancer. Cancer Chemother. Rep. 4: 283–286.
Israel, L. and Halpern, B. N. (1972). Le Corynebacterium parvum dans les cancers avancés. Première évaluation de l’activité thérapeutique de cette immunostimuline. Nouv. Presse Med. 1: 19–23.
Israel, L., Depierre, A., and Chahinian, P. (1971). Combination chemotherapy for 418 cases of advanced cancer. Cancer 27: 1089–1093.
Israel, L., Depierre, A., and Edelstein, R. (1974). Local and systemic effects of intranodular BCG in 25 cases of recurrent melanoma. Proc. Am. Soc. Clin. Oncol. 15:161, Abstr. 711 (March 27–28).
Paslin, D., Dimitrov, N. V., and Heaton, C. (1974). Regression of a transplantable hamster melanoma by intralesional injections of Corynebacterium granulosum. J. Natl. Cancer Inst. 52: 571.
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© 1975 Plenum Press, New York
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Israel, L. (1975). Report on 414 Cases of Human Tumors Treated with Corynebacteria. In: Halpern, B. (eds) Corynebacterium Parvum. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4428-5_44
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DOI: https://doi.org/10.1007/978-1-4613-4428-5_44
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4430-8
Online ISBN: 978-1-4613-4428-5
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