Skip to main content
SpringerLink
Log in

Hypocalciuric Effect of Lithium in Man

  • Chapter
  • First Online:
Phosphate Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 81))

Abstract

Lithium has been shown to inhibit the adenylate cyclase, cyclic-AMP responses to arginine vasopressin in both in vivo (1–3) as well as in vitro assay systems (3–5). Alternatively, it has been shown that lithium may potentiate the cyclic AMP responses to other polypeptide hormones (6–7) although these effects have not been consistent (8). Additionally, lithium has been reported to have divergent effects on urinary calcium excretion in experimental animals (7–10) and man (11). Consequently, we studied the effects of chronic lithium administration on the renal handling of calcium and the renal response to the administration of parathyroid hormone. Though we demonstrated neither a potentiating nor inhibiting effect of lithium on the renal response to parathyroid hormone, we did observe a significant reduction in basal twenty-four hour urinary calcium excretion during lithium therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Forrest, J.N., Cohen, A.D., Torretti, J., Himmelitoat, J.M., and Epstein, F.H.: On the mechanism of lithium-induced diabetes insipidus in man and the rat. J. Clin. Invest. 53:1115, 1974.

    Article  CAS  Google Scholar 

  2. Martinez-Maldonado, M., Stuaroulari-Tsapara, A., Tsaparas, N., Suki, W.N., and Eknoyan, G.: Renal effects of lithium administration in rats. Alterations in water and electrolyte metabolism and the response to vasopressin and cyclic-adeno-sine monophosphate during prolonged administration. J. Lab. Clin. Med. 86:445, 1975.

    CAS  Google Scholar 

  3. Singer, I., Rottenberg, D., Puschett, J.B.: Lithium-induced nephrogenic diabetes insipidus. In vivo and in vitro studies. J. Clin. Invest. 51:1081, 1972.

    Article  CAS  Google Scholar 

  4. Singer, I. and Franko, E.A.: Lithium-induced ADH resistance in toad urinary bladders. Kid. Internat. 3:151, 1973.

    Article  CAS  Google Scholar 

  5. Dousa, T.P.: Interaction of lithium with vasopressin-sensi-tive cyclic AMP system of human renal medulla. Endocrinology 95:1359, 1974.

    Article  CAS  Google Scholar 

  6. Olesen, O.V., Jensen, J., and Thomsen, K.: Effect of lithium on glucagon-stimulated cyclic AMP excretion in rats. Acta Pharmacol, et Toxico. J. 35:403, 1974.

    Article  CAS  Google Scholar 

  7. Olesen, O.V. and Thomsen, K.: Effect of prolonged lithium ingestion on glucagon and parathyroid hormone responses in rats. Acta Pharmacol, et Toxicol. 34:225, 1974.

    Article  CAS  Google Scholar 

  8. Dousa, T. and Hechter, O.: Lithium and brain adenyl cyclase. Lancet 1:834, 1970.

    CAS  PubMed  Google Scholar 

  9. Gotfredsen, C.F. and Rafaelsen, O.J.: Effect of lithium and other psychopharmaca on rat electrolyte metabolism. Int. Phar-macopsychiat. 5:242, 1970.

    Google Scholar 

  10. Birch, N.J. and Jenner, F.A.: The distribution of lithium and its effect on the distribution and excretion of other ions in the rat. Br. J. Pharmac. 47:586, 1973.

    Article  CAS  Google Scholar 

  11. Tupin, J.P., Schlagenhauf, G.K., and Creson, D.L.: Lithium effects on electrolyte excretion. Am. J. Psychiat. 125:536, 1968.

    Article  CAS  Google Scholar 

  12. Gilman, A.G.: Protein binding assay for cyclic nucleotides. Adv. Cyclic Nucleotide Res. 2:9, 1972.

    CAS  PubMed  Google Scholar 

  13. Richardson, J.M., Wolfson, J.A., and Kurtzman, N.A.: Lithium administration and phosphate excretion. Clin. Res. 541A, 1975.

    Google Scholar 

  14. Hullin, R.P., Swinscoe, J.C., McDonald, R., and Dransfield, G.A.: Metabolic balance studies on the effect of lithium salts in manic-depressive psychosis. Brit. J. Psychiat. 114: 1561, 1968.

    Article  CAS  Google Scholar 

  15. Arnst, C.S., Mohs, J.M., Kaplan, S.L., and Burns, T.W.: Evidence for parathyroid failure in magnesium deficiency. Science 177:606, 1972.

    Article  Google Scholar 

  16. Muldowney, F.P., McKenna, T.J., Kyle, L.H., Fraeney, R., and Swan, M.: Parathormone-like effect of magnesium replenishment in steatorrhea. N. Engl. J. Med. 282:61, 1970.

    Article  CAS  Google Scholar 

  17. Suh, S.M., Tashjian, A.H., Matsuo, N., Parkinson, D.K., and Fraser, D.: Pathogenesis of hypocalcemia in primary hypo-magnesemia: normal end-organ responsiveness to parathyroid hormone, impaired parathyroid gland function. J. Clin. Invest. 52:153, 1973.

    Article  CAS  Google Scholar 

  18. Chertow, B.S., Baylink, D.J., Wergedal, J.E., Su, M.H.H., and Norman, A.W.: Decrease in serum immunoreactive parathyroid hormone in rats and in parathyroid hormone secretion in vitro by 1,25 dihydroxycholecalciferol. J. Clin. Invest. 56:668, 1975.

    Article  CAS  Google Scholar 

  19. Mayer, G.P., Habener, J.F., and Potts, J.T., Jr.: Parathyroid secretion in vivo. Demonstration of a calcium independent non-suppressible component of secretion. J. Clin. Invest. 57:678, 1976.

    Article  CAS  Google Scholar 

  20. Fischer, J.A., Blum, J.W., and Binswanger, U.: Acute parathyroid response to epinephrine in vivo. J. Clin. Invest. 52: 2434, 1973.

    Article  CAS  Google Scholar 

  21. Singer, I. and Rotenberg, D.: Mechanisms of lithium action. N. Engl. J. Med. 289:254, 1973.

    Article  CAS  Google Scholar 

  22. Frizel, D., Coppen, A., and Marks, V.: Plasma magnesium and calcium in depression. Brit. J. Psychiat. 115:1375, 1969.

    Article  CAS  Google Scholar 

  23. Mellerup, E.T., Plenge, P., Ziegler, R., and Rafaelsen, O.J.: Lithium effects on calcium metabolism in rats. Int. Pharma-copsychiat. 5:258, 1970.

    Article  Google Scholar 

  24. Walser, M.: Calcium clearance as a function of sodium clearance in the dog. Am. J. Physiol. 200:1099, 1961.

    Article  CAS  Google Scholar 

  25. Massry, S.G., Coburn, J.W., Chapman, L.W., and Kleeman, C.R.: Effect of Na Cl infusion on urinary Ca++ and Mg++ during reduction in their filtered loads. Am. J. Physiol. 213:1218, 1967.

    Article  CAS  Google Scholar 

  26. Brickman, A.S., Massry, S.G., and Coburn, J.W.: Changes in serum and urinary calcium during treatment with hydrochlorothiazide. J. Clin. Invest. 51:945, 1972.

    Article  CAS  Google Scholar 

  27. Costanzo, L.S. and Weiner, I.M.: On the hypocalciuric action of chlorothiazide. J. Clin. Invest. 54:625, 1974.

    Article  Google Scholar 

  28. Widrow, S.H., and Levinsky, N.G.: The effect of parathyroid extract on renal tubular calcium reabsorption in the dog. J. Clin. Invest. 41: 2151, 1962.

    Article  CAS  Google Scholar 

  29. Agus, Z.S., Gardner, L.B., and Goldberg, M.: Effects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate. Am. J. Physiol. 224: 1143, 1973.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Renal Div., Dept. of Med. and Dept. of Psychiatry, Univ. of Colo. Med. Ctr., and Endocr. Res. Lab., Mayo Clinic Denver, Colorado and Rochester, Minnesota, USA

    P. D. Miller M.D., S. L. Dubovsky M.D., R. W. Schrier M.D., K. M. McDonald M.D. & C. Arnaud M.D.

Authors
  1. P. D. Miller M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. L. Dubovsky M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. W. Schrier M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. M. McDonald M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. Arnaud M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany

    Eberhard Ritz

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Springer Science+Business Media New York

About this chapter

Cite this chapter

Miller, P.D., Dubovsky, S.L., Schrier, R.W., McDonald, K.M., Arnaud, C. (1977). Hypocalciuric Effect of Lithium in Man. In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4217-5_19

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-4219-9

  • Online ISBN: 978-1-4613-4217-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation