Abstract
When an organ is subjected to anoxia or an increased work load, its rates of A TP utilization and synthesis change. Such changes are accompanied by adjustments in the concentrations of many intermediates of energy metabolism, including ATP, ADP, AMP, creatine phosphate, and creatine. However, changes in the concentration of free A TP are relatively small.
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References
Goodman MN, Lowenstein JM: The purine nucleotide cycle: Studies of ammonia production by skeletal muscle in situ and in perfused preparations. J BioI Chem 252: 5054–5060, 1977.
Lowenstein JM, Goodman MN: The purine nucleotide cycle in skeletal muscle. Fed Proc 37: 2308–2312, 1978.
Nishiki K, Erecinska M, Wilson DF: Energy relationships between cytosolic metabolism and mitochondrial respiration in rat heart. Am J Physiol 234: C73–C81, 1978.
McGilvery RW, Murray TW: Calculated equilibria of phosphocreatine and adenosine phosphates during utilization of high energy phosphate by muscle. J Biol Chem 249: 5845–5850, 1974.
Frick GP, Lowenstein JM: Vectorial production of adenosine by 5′-nucleotidase in the perfused rat heart. J Biol Chern 253: 1240–1244, 1978.
Klingenberg M: The ADP ATP translocation in mitochondria, a membrane potential controlled transport. J Membr Biol 56: 97–105, 1980.
Berne RM, Foley DH, Watkinson WP, Miller WL, Winn HR, Rubio R: Role of adenosine as a mediator of metabolic vasodilation in the heart and brain: A brief overview and update, in Baer HP, Drummond GI (eds): Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides. New York, Raven Press, 1979, pp 117–126.
Frick GP, Lowenstein JM: Studies of 5′-nucleotidase in the perfused rat heart: Including measurements of the enzyme in perfused skeletal muscle and liver. J Biol Chem 251: 6372–6378, 1976.
Rubio R, Berne RM, Dobson JG Jr: Site of adenosine production in cardiac and skeletal muscle. Am J Physiol 225: 938–953, 1973.
Burger R, Lowenstein JM: Preparation and properties of 5′-nucleotidase from smooth muscle of small intestine. J Biol Chem 245: 6274–6280, 1970.
Arch JRS, Newsholme EA: The control of metabolism and the hormonal role of adenosine. Essays Biochem 14: 82–123, 1978.
Hoffman PC, Okita GT: Penetration of ATP into the myocardium. Proc Soc Exp Biol Med 119: 573–576, 1965.
Williamson JR, DiPietro DL: Evidence for extracellular enzymic activity of the isolated perfused rat heart. Biochem J 95: 226–232, 1965.
Baer HP, Drummond GI: Catabolism of adenine nucleotides by the isolated perfused rat heart. Proc Soc Exp Biol Med 127: 33–36, 1968.
Widnell CC, Schneider Y-J, Pierre B, Baudhuin P, Trouet A: Evidence for a continual exchange of 5′ -nucleotidase between the cell surface and cytoplasmic membranes in cultured rat fibroblasts. Cell 28: 61–70, 1982.
Zachowski A, Aubry J, Jonkman-Bark G, Lelievre L: Localization of the catalytic site of 5′nucleotidase at the inner surface of murine plasmocytoma plasma membranes. FEBS Lett 75: 197–200, 1977.
Kidwai AM, Radcliffe MA, Duchon G, Daniel EE: Isolation of plasma membrane from cardiac muscle. Biochem Biophys Res Commun 45: 901–910, 1971.
Gibson WB, Drummond GI: Properties of 5′-nucleotidase from avian heart. Biochemistry 11: 223–229,1972.
Little JS, Widnell CC: Evidence for the translocation of 5′ -nucleotidase across hepatic membranes in vivo. Proc Natl Acad Sci USA 72: 4013–4017, 1975.
Baer H-P, Drummond GI, Duncan EL: Formation and deamination of adenosine by cardiac muscle enzymes. Mol Pharmacol 2: 67–76, 1966.
Sullivan JM, Alpers JB: In vitro regulation of rat heart 5′ -nucleotidase by adenine nucleotides and magnesium. J Biol Chem 246: 3057–3063, 1971.
Naito Y, Lowenstein JM: 5′-Nucleotidase from rat heart. Biochemistry 20: 5188–5194, 1981.
Sanui H: Measurement of inorganic orthophosphate in biological materials: Extraction properties of butyl acetate. Anal Biochm 60: 489–504, 1974.
Van Den Berghe G, Van Pottelsberghe C, Hers H-G: A kinetic study of the soluble 5′-nucleotidase of rat liver. Biochem J 162: 611–616, 1977.
Itoh R: Purification and some properties of cytosol 5′-nucleotidase from rat liver. Biochim Biophys Acta 657: 402–410, 1981.
Fritzson P: Nucleotidase activities in the soluble fraction of rat liver homogenate: Partial purification and properties of a 5′-nucleotidase with pH optimum 6.3. Biochim Biophys Acta 178: 534–541, 1969.
Naito Y, Tsushima K: Cytosol 5′-nucleotidase from chicken liver: Purification and some properties. Biochim Biophys Acta 438: 159–168, 1976.
Naito Y, Itoh R, Tsushima K: 5′-Nucleotidase of chicken liver: A comparison of soluble 5′nucleotidase activities in chicken and rat livers. Int J Biochem 5: 807–810, 1974.
Storer AC, Cornish-Bowden A: Concentration of MgATp2− and other ions in solution: Calculation of the true concentrations of species present in mixtures of associating ions. Biochem J 159: 1–5, 1976.
Schultz V, Lowenstein JM: The purine nucleotide cycle: Studies of ammonia production and interconversion of adenine and hypoxanthine nucleotides and nucleosides by rat brain in situ. J Biol Chem 253: 1938–1943, 1978.
Williamson JR: Glycolytic control mechanisms: I. Inhibition of glycolysis by acetate and pyruvate in the isolated, perfused rat heart. J Biol Chem 240: 2308–2321, 1965.
Liang C-S, Lowenstein JM: Metabolic control of the circulation. Effects of acetate and pyruvate. J Clin Invest 62: 1029–1038, 1978.
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Lowenstein, J.M., Yu, MK., Naito, Y. (1983). Regulation of Adenosine Metabolism by 5’-Nucleotidases. In: Berne, R.M., Rall, T.W., Rubio, R. (eds) Regulatory Function of Adenosine. Developments in Pharmacology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3909-0_8
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DOI: https://doi.org/10.1007/978-1-4613-3909-0_8
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