Abstract
Although it has been suspected for some time that precise coupling exists between blood flow and parenchymal cell metabolism, it has only recently been clearly demonstrated by the availability of more sophisticated modern techniques. The findings clearly indicate that metabolism and blood flow are regulated, at least in part, by common feedback signals. One such signal is adenosine. The release of adenosine into the surrounding interstitial fluid is associated with parenchymal cell ATP-dependent functions such as transmembrane electrical regenerative processes, muscle contraction, and cell secretion (transmitters, hormones, ions). These effects of adenosine are most likely exerted at the level of the cell membrane through changes in adenylate cyclase activity or ionic permeability to Ca2+ or K+ or Cl−. This chapter will be restricted to the effects of adenosine on ionic membrane permeation.
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© 1983 Martinus Nijhoff Publishers, The Hague
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Rubio, R., Knabb, M.T., Tsukada, T., Berne, R.M. (1983). Mechanisms of Action of Adenosine on Vascular Smooth Muscle and Cardiac Cells. In: Berne, R.M., Rall, T.W., Rubio, R. (eds) Regulatory Function of Adenosine. Developments in Pharmacology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3909-0_20
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DOI: https://doi.org/10.1007/978-1-4613-3909-0_20
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