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Immune Modulation Aspects of Blood Transfusion in Transplantation Practice

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Transplantation and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 10))

Abstract

There are many ways to alter the immune response of a recipient to an organ graft. Sofar, the most successful approaches in renal transplantation are matching of donors and recipients for the HLA-A, -B and -DR antigens, the use of immunosuppressive drugs and pretransplant blood transfusions. The latter factor has received considerable attention since Opelz and Terasaki in 1973 (1) reported that kidney graft recipients who never had received blood transfusions prior to transplantation had a very poor kidney graft survival. Since then, many different protocols have been designed for experimental and clinical studies to investigate the role of pretransplant blood transfusions in renal transplantation.

This work was in part supported by the Dutch Foundation for Medical Research (FUNGO) which is subsidized by the Dutch Organization for the Advancement of Pure Research (ZWO), the J. A. Cohen Institute for Radiopathology and Radiation Protection (IRS) and the Kuratorium für Heimdialyse Neu-Isenburg, Germany.

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  1. G. G. Persijn
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Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga  & P. C. Das  & 

  2. Ruprecht Karls University, Heidelberg, Germany

    G. Opelz

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© 1984 Springer Science+Business Media Dordrecht

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Persijn, G.G. (1984). Immune Modulation Aspects of Blood Transfusion in Transplantation Practice. In: Smit Sibinga, C.T., Das, P.C., Opelz, G. (eds) Transplantation and Blood Transfusion. Developments in Hematology and Immunology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3840-6_6

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  • DOI: https://doi.org/10.1007/978-1-4613-3840-6_6

  • Publisher Name: Springer, Boston, MA

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