Abstract
Previous chapters have documented the close relationship between activation of blood coagulation and the growth and metastasis of malignant tumors. A variety of tumor-related mechanisms have been shown to participate in the activation of the coagulation cascade and the initiation of platelet aggregation. In addition to playing a role in tumor homeostasis, these alterations can lead to the development of a “hypercoagulable state” with associated clinical and laboratory manifestations. This chapter will review the laboratory abnormalities and the associated clinical syndromes which accompany the hypercoagulable state in cancer patients.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Trousseau A. CLinique Medicale de l’Hotel-Dieu de Paris, The New Sydenham Society, London, England 3: 94, 1865.
Sack GH Jr., Levin J and Bell W. Medicine 56: 1–37, 1977.
Sproule EE. An. J. Cancer 34: 566–585, 1938.
Thompson CM and Roger RL. Am. J. ted. Sci. 223: 469–475, 1952.
Ambrus JL, Ambrus CM, Mink IB and Pickren JW. J. Med. 6: 61–64, 1975.
Anylan WG, Shingleton WW and Delaughter GD Jr. J. Am. ted. Assoc. 161: 964–970, 1956.
Hoerr SO and Harper JR. J. Am. ted. Assoc. 164: 2033–2044, 1957.
Soong BCF and Miller SO. Cancer (Philadelphia) 25: 867–873, 1970.
Hull R, Hirsch J, Sackett DL, Powers P, Turpie AGG and Walker I. N. Engl. J. ted. 296: 1497–1500, 1977.
Hefner RR Jr. Neurology 21: 840–846, 1971.
Lieberman JS, Borrero J, Urdanetta E and Wright IS. J. An. Med. Assoc. 177: 542–545, 1961.
Durhan RH. Arch. Intern. Med. 96: 380–386, 1955.
Ambrus JL, Ambrus CM, Pickern J, Soldes S and Bross I. J. Med. 6: 433–458, 1975.
Weese RB, Toimey DC, Holland JF and Weinberg VE. Cancer Treat. Rep. 65: 677–679, 1981.
Pineo GF, Brain MC, Galkes AS, Hirsh J, Hatton MWC and Regoeczi E. Ann. N.Y. Acad. Sci. 230: 262–270, 1974.
Owen CA Jr. and Bowie CJW. Mayo Clin. Proc. 49: 673–679, 1974.
Peuscher JW. Neth. J. Med. 24: 23–35, 1981.
Polliack A. An. J. ain. Pathol. 56: 155–161, 1971.
Gralnick HR, Marchesi S and Givelber H. Blood 40: 709–718, 1972.
Gralnick HR and Abrell E. Br. J. Haematol. 24: 89–99, 1973.
Goualt-Heilman M, Chardon E, Sultan E and Josse F. Br. J. Haematol. 30: 151–158, 1975.
Brain MC, Azzopardi JG and Baker LRI. Br. J. Haematol. 18: 183–193, 1970.
Belt RJ, Leite C, Haas CD and Stephens RL. J. Am. Med. Assoc. 239: 2571–2574, 1978.
Al-Mondhiry H. Thromb. Diath. Haanorrh. 34: 181–193, 1975.
Sun NC, McAfee WM, Hum GJ and Weiner JM. Am. J. Clin. Pathol. 71: 10–16, 1979.
Hagedorn AB, Bowie EJW, Elveback LR and Owen CA. Mayo Clin. Proc. 49: 649–653, 1974.
Carlsson S. Acta Chir. Scand. 139: 499–502, 1973.
Miller SP, Sanchez-Avalos J, Stefanski T and Zuckerman L. Cancer (Philadelphia) 20: 1452–1465, 1967.
Rasche H and Dietrich M. Eur. J. Cancer 13: 1053–1064, 1977.
Cooper HA, Bowie EJW and Owen CA Jr. Mayo Clin. Proc. 49: 654–657, 1974.
Kies MS, Posch JJ, Giolma JP and Rubin RN Cancer (Philadelphia) 46: 831–837,1980
Harker LA and Slichter SJ. N. Engl. J. Med. 287: 999–1005, 1972.
Slichter SJ and Harker LA. Ann. N.Y. Acad. Sci. 230: 252–261, 1974.
Johannson S, Kutti J and Olson LB. Acta Pathol. Microbiol. Scand. 86: 505–511, 1978.
Bidet JN, Ferriere JP, Besse G, Collet FH, Gaillard G and Plagne R. Thromb. Res. 19: 429–433, 1980.
Schernthaner G, Ludwig H and Silberbauer K. Acta Hematol. 62: 219–222, 1970.
Levin L and Conley A Arch. Intern. Med. 114: 497–500, 1964.
Davis RB, Theologides A and Kennedy BJ. Ann. Intern. Med. 71: 67–80, 1969.
Shaikh BS and Bullard V. Blood 50 (Suppl. 1): 252, 1977.
Jung SM, Isoliisa I, Kinoshita K and Yamasaki H. Thromb. Haemostasis 46: 30, 1981.
Yamamura T, Matsunoto H, Maruyama Y, Wada T and Yamanaka M. Thromb. Haemostasis 46: 31, 1981.
Karpatkin S and Pearlstein E. Ann. Intern. Med. 95: 636–641, 1981.
Zacharski LR, Rickles FR, Henderson WG, Martin JF, Forman WB, van Eeckhout JP, Cornell CJ and Forcier RJ. Am. J. Clin. Oncol, (in press), 1983.
Collen D and DeCock F. Thromb. Res. 5: 777–779, 1974.
Shunan MA and Majerus FW. J. Clin. Invest. 58: 1249–1258, 1976.
Merskey C, Johnson AJ, Harris JU, Wang MT and Swain S. Br. J. Haematol. 44: 655–670, 1980.
Bettigole RE, Himelstein ES, Clifford GO and Mayer K. J. Nucl. Med. 10: 322–323, 1969.
Collen D, Tytgat GN, CLaeys H and Piessens R. Br. J. Haematol. 22: 681–700, 1972.
Takeda Y. J. CLin. Invest. 45: 103–111, 1966.
Mombelli G, Roux A, Haeberli A and Straub IV. Blood 60: 381–388, 1982.
Lyman GH, Bettigole RE, Robson E, Ambrus JL and Urban H. Cancer (Philadelphia) 1: 1113–1122, 1978.
Yoda Y and Abe T. Thomb. Haanostasis 46: 706–709, 1981.
Robson E, Murawski GF and Bettigole RE. Thromb. Haemostasis 37: 484–508, 1977.
Ruegg R and Straub PW. J. Lab. Clin. Med. 95: 842–856, 1980.
Hiramoto R, Bernecky J, Jurandowski J and Pressman D. Cancer Res. 20: 592–593, 1960.
Plow EF and Edgington TS. J. Clin. Invest. 56: 30–38, 1975.
Nossel HL, Yudelman I, Canfield RE, Buttler VP Jr., Spanondis K, Wilner GD and Qureshi GD. J. Clin. Invest. 54: 43–53, 1974.
Cronlund M, Hardin J, Burton J, Lee L, Haber E and Bloch KJ. J. CLin. Invest. 58: 142–151, 1976.
Myers TJ, Rickles FR, Barb C and Cronlund M. Blood 57: 518–525, 1981.
Peuscher PW, CLeton FJ, Armstrong L, Stoepman-van Dalen EA, van Mourik JA and van Aken WG. J. Lab. CLin. ted. 96: 5–14, 1980.
Rickles FR, Edwards RL, Barb C and Cronlund M. Cancer (Philadelphia) 51: 301–307, 1983.
Yudelman I and Greenberg J. Blood 59: 787–792, 1982.
Strauli P, Barrett AJ and Baici A, Eds. Proteinases and Tumor Invasion, Raven Press, New York, 1980.
Bilzekian SB and Nossel HL. Blood 50: 21–28, 1977.
Damus PS and Wallace GA. Thromb. Res. 6: 27–38, 1976.
Rubin RN, Kies MS and Posch JJ. Thromb. Res. 18: 353–360, 1980.
Wilner GD, Chatpar P and Horowitz J. J. Lab. Clin., Med. 91: 205–213, 1978.
Rickles FR, Edwards RL and Zacharski LR. Proceedings of the 1981 International Istanbul Symposiim, Istanbul, Turkey, in press, 1983.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Edwards, R.L., Rickles, F.R. (1984). Hemostatic Alterations in Cancer Patients. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_22
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3831-4_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3833-8
Online ISBN: 978-1-4613-3831-4
eBook Packages: Springer Book Archive