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Interaction of Tumor Cells with the Basement Membrane of Endothelium

  • Chapter
Hemostatic Mechanisms and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 22))

Abstract

Intense clinical and experimental interest continues to be placed on cancer invasion and metastasis since these pathologic processes are widely considered to be the major cause of death resulting from malignant disease (1–3). In addition, the properties of invasion and metastasis define the malignant phenotype of tumor cells (1–3). Tumor cells with metastatic potential, which comprise only a subpopulation of the heterogenous cells within the primary neoplasm, can only give rise to secondary metastatic colonization following numerous and complex tumor cell-host interactions (4); for example, invasive, metastatic cells penetrate a number of host extracellular matrices and barriers. This chapter will review recent findings dealing with the interaction of malignant cells with one particular type of extracellular matrix that is encountered by invasive tumor cells at several steps of the metastatic process: the basement membrane. Following an overview dealing with the structure and function of basement membranes, including vascular basement membranes, emphasis will be placed on the discrete steps involved in tumor cell-basement membrane interaction: tumor cell attachment, basement membrane dissolution mediated by tumor cell-derived proteolytic enzymes and subsequent tumor cell locomotion through localized domains of degraded basement membrane in the proximity of invading tumor cells.

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References

  1. Liotta LA and Hart IR. Tumor Invasion and Metastasis. Martinus Nijhoff, The Hague, 1982.

    Google Scholar 

  2. Grundmann E. Metastatic Timor Growth. Gustav Fischer Verlag, Stuttgart, 1980.

    Google Scholar 

  3. Strauli P, Barrett AJ and Baici A. Proteinases and Timor Invasion. Raven Press, New York, 1980.

    Google Scholar 

  4. Fidler IJ, Gersten EM and Hart IR. Mv. Cancer Res. 28: 149–250, 1978.

    CAS  Google Scholar 

  5. Liotta LA, Garbisa S and Tryggvason K. In: Tumor Invasion and Metastasis (Eds. Liotta LA and Hart IR), Martinus Nijhoff, The Hague, pp. 319–333, 1982.

    Google Scholar 

  6. Liotta LA, Tryggvason K, Garbisa S, Gehron-Robey P and Murray JC. In: Metastatic Tumor Growth (Ed. Grundmann E), Gustav Fischer Verlag, Stuttgart, pp. 21–30, 1980.

    Google Scholar 

  7. Vracko R. An. J. Pathol. 77: 314–320, 1974.

    CAS  Google Scholar 

  8. Daroczy J, Feldmann J and Kiraly K. Front. Matrix Biol. 7: 208–234, 1979.

    Google Scholar 

  9. Timpl R, Rohde H, Gehron-Robey P, Rennard S, Foidart JM and Martin GR. J. Biol. Chem. 254: 9933–9937, 1979.

    PubMed  CAS  Google Scholar 

  10. Mosesson MW and Amrani DL. Blood 56: 145–148, 1980.

    PubMed  CAS  Google Scholar 

  11. Alitalo K and Vaheri A. Adv. Cancer Res. 37 111–158, 1982.

    Article  PubMed  CAS  Google Scholar 

  12. Bernfield MR, Cobn RH and Banerjee SD. An. Zool. 13: 1067–1083, 1973.

    CAS  Google Scholar 

  13. Caulfield JP and Farquhar MG. J. Cell Biol. 63: 883–903, 1974.

    Article  PubMed  CAS  Google Scholar 

  14. Hassell J, Gehron-Robey R, Barrach H, Wilczek J, Rennard S and Martin GR. Proc. Natl. Acad. Sci. USA 77: 4494–4498, 1981.

    Article  Google Scholar 

  15. Kefalides NA. Biology and Chemistry of Basement Membranes. Academic Press, New York, 1978.

    Google Scholar 

  16. Miller EJ. Mol. Cell. Biochem. 13: 165–192, 1976.

    Article  PubMed  CAS  Google Scholar 

  17. Bornstein P and Sage H. Annu. Itev. Biochem. 49: 957–1003, 1980.

    Article  CAS  Google Scholar 

  18. Timpl R, Martin GR, Bruckner P, Wick G and Wiedemann H. Eur. J. Biochem. 84: 43–50, 1978.

    Article  PubMed  CAS  Google Scholar 

  19. Burgeson RE, EL Adli FA, Kaitila II and Hollister DW. Proc. Natl. Acad. Sci. USA 73. 2579–2580, 1976.

    Article  PubMed  CAS  Google Scholar 

  20. Madri JA and Furthmayr H. An. J. Pathol. 94: 323–331, 1980.

    Google Scholar 

  21. Vlodavsky I, Schirrmacher V, Ariav Y and Fuks Z. Invasion Metastasis 3: 81–97, 1983.

    PubMed  CAS  Google Scholar 

  22. Kramer RH, Gonzalez R and Nicolson GL. Int. J. Cancer 26 639–644, 1980.

    Article  PubMed  CAS  Google Scholar 

  23. Vlodavsky I, Ariav Y, Atanon R and Fuks Z. Exp. Cell Res. 140: 149–159, 1982.

    Article  PubMed  CAS  Google Scholar 

  24. Nicolson GL, Irimura T, Gonzalez RS and Rusohlahti E. Exp. Cell Res. 135: 461–465, 1981.

    Article  PubMed  CAS  Google Scholar 

  25. Warren BA and Vales O. Br. J. Exp. Pathol. 53 301–311, 1972.

    PubMed  CAS  Google Scholar 

  26. Poste G and Fidler IJ. Nature (London) 283 139–146, 1980.

    Article  CAS  Google Scholar 

  27. Nicolson GL. In: Tumor Invasion and Metastasis (Eds. Liotta LA and Hart IR), Martinus Nijhoff, The Hague, pp. 319–333, 1982.

    Google Scholar 

  28. Kleinnan HK, Klebe RJ and Martin GR. J. Cell Biol. 88: 473–485, 1981.

    Article  Google Scholar 

  29. Terranova VP, Rohrbach DH and Martin GR. Cell 22: 719–726, 1980.

    Article  PubMed  CAS  Google Scholar 

  30. Terranova VP, Liotta LA, Russo RG and Martin GR. Cancer Res. 42: 2265–2269, 1982.

    PubMed  CAS  Google Scholar 

  31. Rao CN, Margulies IMK, Tralka TS, Terranova VP, Madri JA and Liotta LA. J. Biol. Chem. 257: 9740–9744, 1982.

    PubMed  CAS  Google Scholar 

  32. Grinnell F and Field MK. Cell 18 117–128, 1979.

    Article  Google Scholar 

  33. Miller EJ and Matukas VJ. Proc. Natl. Acad. Sci. USA 64: 1264–1268, 1969.

    Article  PubMed  CAS  Google Scholar 

  34. Murray JC, Liotta LA, Rennard SI and Martin GR. Cancer Res. 40: 347–351, 1980.

    PubMed  CAS  Google Scholar 

  35. Vlodavsky I and Gospodarowicz D. Nature (London) 289. 304–306, 1981.

    Article  CAS  Google Scholar 

  36. Varani J, Lovett EJ, McCoy JP, Shibata S, Maddox DE, Goldstein IJ and Wicha M. Am. J. Pathol. 111: 27–34, 1983.

    PubMed  CAS  Google Scholar 

  37. Hogan B. Nature (London) 290 737–738, 1981.

    Article  CAS  Google Scholar 

  38. Johansson S, Kjellen L, Hook M and Timpl R. J. Cell Biol. 90: 260–264, 1981.

    Article  PubMed  CAS  Google Scholar 

  39. Damon MY. In Vitro 18: 997–1003, 1982.

    Article  Google Scholar 

  40. Crouchman JR, Hook M, Rees DA and Timpl R. J. Cell Biol. 96: 177–183, 1983.

    Article  Google Scholar 

  41. Leivo I. J. Histochem. Cytochem. 31: 35–45, 1983.

    Article  PubMed  CAS  Google Scholar 

  42. Macarak EJ and Howard PS. J. Cell. Physiol. 116 76–86, 1983.

    Article  PubMed  CAS  Google Scholar 

  43. Kennedy DW, Rohrbach DH. Martin GR, Manoi T and Yamada KM. J. Cell. Physiol. 114: 257–262, 1983.

    Article  PubMed  CAS  Google Scholar 

  44. Terranova VP, Rao CN, Kalebic T, Margulies IM and Liotta LA. Proc. Natl. Acad. Sci. USA 80: 444–448, 1983.

    Article  PubMed  CAS  Google Scholar 

  45. Rao CN, Barsky SH, Terranova VP and Liotta LA. Biochem. Biophys. Res. Commun. 111: 804–808, 1983.

    Article  PubMed  CAS  Google Scholar 

  46. Malinoff HL and Wicha MS. J. Cell Biol. 96. 1475–1479, 1983.

    Article  PubMed  CAS  Google Scholar 

  47. Engel J, Odermatt E, Engel A, Madri JA, Furthmayr H, Rohde H and Timpl R. J. Mol. Biol. 150 97–120, 1981.

    Article  PubMed  CAS  Google Scholar 

  48. Timpl R, Engel J and Martin GR. Trends Biochen. Sci. 8: 207–209, 1983.

    Article  CAS  Google Scholar 

  49. Sakashita S, Engvall E and Ruoslahti E. FEBS Lett. 116: 243–246, 1980.

    Article  PubMed  CAS  Google Scholar 

  50. Delrosso M, Cappelletti R, Viti M, Vanucchi S and Chiarngi V. Biochem. J. 199: 699–704, 1981.

    CAS  Google Scholar 

  51. Rohde H Bachinger HP and Timpl R. Hoppe-Seyler’s Z. Physiol. Chem. 361: 1651–1660, 1980.

    Article  CAS  Google Scholar 

  52. Liotta LA, Goldfarb RH and Terranova VP. Thromb. Res. 21: 663–673, 1981.

    Article  PubMed  CAS  Google Scholar 

  53. Goldfarb RH, Liotta LA and Garbisa S. Proc. M. Assoc. Cancer Res. 22: 59, 1981.

    Google Scholar 

  54. Liotta LA, Goldfarb RH, Brundage R, Siegal GP, Terranova VP and Garbisa S. Cancer Res. 41: 4629–4636, 1981.

    PubMed  CAS  Google Scholar 

  55. Rao CN, Margulies IMK, Goldfarb RH, Madri JAV Woodley DT and Liotta LA. Arch. Biochem. Biophys. 219: 65–70, 1982.

    Article  CAS  Google Scholar 

  56. Ott U, Odermatt E, Engel J, Furthmayr H and Timpl R. Eur. J. Biochem. 123: 63–72, 1982.

    Article  PubMed  CAS  Google Scholar 

  57. Timpl R, Johansson S, van Delden V, Oberbaumer I and Hook M. J. Biol. Chem. 258: 8922–8927, 1983.

    PubMed  CAS  Google Scholar 

  58. Giavazzi R and Hart IR. Exp. Cell. Res. 146: 391–399, 1983.

    Article  PubMed  CAS  Google Scholar 

  59. Speziale P, Hook M, Wadstrom T and Timpl R. FEBS Lett. 146: 55–58, 1982.

    Article  PubMed  CAS  Google Scholar 

  60. Yogeeswaran G. Mv. Cancer Res. 38: 289–350, 1983.

    CAS  Google Scholar 

  61. Schirrmacher V, Altevogt P, Fogel M, Dennis J, Waller CA, Barz D, Schvjartz R, Cheingsong-Popov R, Springer G, Robinson PJ, Nebe T, Brossmer W, Vlodavsky I, Pawletz N, Zimmerman H-P and Uhlenbruck G. Invasion Metastasis 2: 313–360, 1982.

    CAS  Google Scholar 

  62. Nicolson GL. Biochim. Biophys. Acta. 695 113–176, 1982.

    PubMed  CAS  Google Scholar 

  63. Yogeeswaran G and Salk PL. Science 212 1514–1516, 1981.

    Article  PubMed  CAS  Google Scholar 

  64. Dermis J, Waller C, Timpl R and Schirrmacher V. Nature (London) 300. 274–275, 1982.

    Article  Google Scholar 

  65. Fogel M, Altevogt P and Schirrmacher V. J. Exp. Med. 157: 371–376, 1983.

    Article  PubMed  CAS  Google Scholar 

  66. Sinha BK and Goldenberg GJ. Cancer (Philadelphia) 34. 1956–1961, 1974.

    Article  CAS  Google Scholar 

  67. Irimura T, Gonzalez R and Nicolson GL. Cancer Res. 41 3411–3418, 1981.

    PubMed  CAS  Google Scholar 

  68. Irimura T and Nicolson GL. J. Supramol. Struct. Cell. Biochem. 17 325–336, 1981.

    Article  PubMed  CAS  Google Scholar 

  69. Turner GA. Invasion Metastasis 2: 197–216, 1982.

    PubMed  CAS  Google Scholar 

  70. Stamper HB and Woodruff JJ. J. Exp. Med. 144: 828–833, 1976.

    Article  PubMed  Google Scholar 

  71. Chin Y, Carey GD and Woodruff JJ. J. Inmunol. 129: 1911–1915, 1982.

    CAS  Google Scholar 

  72. Nicolson GL. In: Cancer Achievements, Challenges and Prospects for the 1980’s (Eds. Burchenal JH and Oettgen HF), Grune and Stratton, New York, pp. 477–490, 1980.

    Google Scholar 

  73. Brunson KW, Beattie G and Nicolson GL. Nature (London) 272 543–545, 1978.

    Article  CAS  Google Scholar 

  74. Karpatkin S and Pearlstein E. Ann. Intern. Med. 95: 636–641, 1981.

    PubMed  CAS  Google Scholar 

  75. Honn KV, Busse WD and Sloane BF. Biochem. Pharmacol. 32: 1–11, 1983.

    Article  PubMed  CAS  Google Scholar 

  76. Liotta LA, Goldfarb RH, Brundage R, Siegal GP, Terranova V and Garbisa S. Cancer Res. 41: 4629–4636, 1981.

    PubMed  CAS  Google Scholar 

  77. Liotta LA, Thorgeirsson UP and Garbisa S. Cancer Metastasis Rev. 1: 277–288, 1982.

    Article  PubMed  CAS  Google Scholar 

  78. Goldfarb RH. In: Tumor Invasion and Metastasis (Eds. Liotta LA and Hart IR), Martinus Nijhoff, The Hague, pp. 375–390, 1982.

    Google Scholar 

  79. Jones PA and De Clerck YA. Cancer Metastasis Rev. 1: 289–317, 1982.

    Article  PubMed  CAS  Google Scholar 

  80. Pauli BU, Schwartz Dh, Thonar EJ-M and Kuettner KE. Cancer Metastasis Rev. 2: 129–152, 1983.

    Article  PubMed  CAS  Google Scholar 

  81. Mareel M. Cancer Metastasis Rev. 2: 201–218, 1983.

    Article  PubMed  CAS  Google Scholar 

  82. Liotta LA, Abe S, Gehron-Robey P and Martin GR. Proc. Natl. Acad. Sci. USA 76 2268–2272, 1979.

    Article  PubMed  CAS  Google Scholar 

  83. Liotta LA, Tryggvason K, Garbisa S, GehronrRobey P and Abe S. Biochemistry 20: 100–104, 1981.

    Article  PubMed  CAS  Google Scholar 

  84. Salo T, Uotta LA and Tryggvason K. J. Biol. Chem. 258: 3058–3063, 1983.

    PubMed  CAS  Google Scholar 

  85. Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz CM and Shafie S. Nature (London) 284: 67–68, 1980.

    Article  CAS  Google Scholar 

  86. Garbisa S, Kniska K, Tryggvason K, Foltz C and Liotta IA. Cancer Lett. 9: 359–366, 1980.

    Article  PubMed  CAS  Google Scholar 

  87. Liotta IA, Lanzer WL and Garbisa S. Biochem. Biophys. Res. Commun. 98 184–190, 1981.

    Article  CAS  Google Scholar 

  88. Mainardi CL, Seyer JM and Kang AH. Biochem. Biophys. Res. Commun. 97: 1108–1115, 1980.

    Article  CAS  Google Scholar 

  89. Mainardi CL, Dixit SN and Kang AH. J. Biol. Chem. 255: 5435–5441, 1980.

    PubMed  CAS  Google Scholar 

  90. Liotta LA, Wicha MS, Foidart JM, Rennard SI, Garbisa S and Kidwell WR. Lab. Invest. 41: 511–518, 1979.

    PubMed  CAS  Google Scholar 

  91. Reich E. In Molecular Basis of Degradative Processes (Eds. Berlin RD, Herrman H, Lepow IR and Tanzer JM), Academic Press, New York, pp. 155–169 1978.

    Google Scholar 

  92. Goldfarb RH. Annu. Rep. Med. Chem. 18; 257–264, 1983.

    Article  CAS  Google Scholar 

  93. Werb Z, Banda MJ and Jones PA. J. Exp. Med. 152: 1340–1357, 1980.

    Article  PubMed  CAS  Google Scholar 

  94. Jones PA and Scott-Burden T. Biochem. Biophys. Res. Commun. 86: 71–77, 1979.

    Article  PubMed  CAS  Google Scholar 

  95. Jones PA and Werb Z. J. Exp. Med. 152: 1527–1536, 1980.

    Article  PubMed  CAS  Google Scholar 

  96. Jones PA and DeClerck Y. Cancer Res. 40: 3222–3227, 1980.

    PubMed  CAS  Google Scholar 

  97. Sheela S and Barrett JC. Carcinogenesis 3: 363–369, 1982.

    Article  PubMed  CAS  Google Scholar 

  98. Nicolson GL, Winkelhake JL and Nussey AC. In: Fundamental Aspects of Metastasis (Ed. Weiss L), North Holland, Ansterdam, pp. 291–303, 1976.

    Google Scholar 

  99. Wang BS, McLoughlin GA, Richie JP and Mannick JA. Cancer Res. 40: 288–292, 1980.

    PubMed  CAS  Google Scholar 

  100. Talmadge JE, Starkey JR and Stanford DR. J. Supramol. Struct. Cell. Biochem. 15: 139–151, 1981.

    Article  PubMed  CAS  Google Scholar 

  101. Ossowski L and Reich E. Cancer Res. 40: 2300–2309, 1980.

    PubMed  CAS  Google Scholar 

  102. Corasanti JG, Celik C, Camiolo SM, Mittelman A, Evers AJC, Barbasch A, Hobika GH and Markus G. J. Natl. Cancer Inst. 65: 345–351, 1980.

    PubMed  CAS  Google Scholar 

  103. Evers JL, Patel J, Madeja JM, Schneider SL, Hobika GH, Camiolo S and Markus G. Cancer Res. 42. 219–226, 1982.

    PubMed  CAS  Google Scholar 

  104. Pollard M, Luckert PH and Ruckner-Kardoss E. Fed. Proc. Fed. An. Soc. Exp. Biol. 42 773, 1983.

    Google Scholar 

  105. Roblin R. Cancer Biol. Rev. 2: 59–94, 1981.

    Google Scholar 

  106. Cederholm-Williams SA. Invasion Metastasis 1: 85–97, 1981.

    PubMed  CAS  Google Scholar 

  107. Barrett JC and Sheela S. In: Timor Invasion and Metastasis (Eds. Liotta LA and Hart IR), Martinus Nijhoff, The Hague, pp. 359–374, 1982.

    Google Scholar 

  108. Markus G. In: Progress in Fibrinolysis, Vol 6 (Eds. Davidson JF, Nilsson IM, Astedt B), Churchill-Livingstone, Edinburgh, pp. 587–604, 1981.

    Google Scholar 

  109. Paranjpe M, Engel L, Young N and Liotta LA. Life Sci. 26: 1223–1231, 1980.

    Article  PubMed  CAS  Google Scholar 

  110. Salo T, Liotta LA, Keski-Oja J, Turpeenniemi-Hujanen T and Tryggvason K. Int. J. Cancer 30: 669–673, 1982.

    Article  PubMed  CAS  Google Scholar 

  111. Laug WE, DeClerck YA and Jones PA. Cancer Res. 43: 1827–1834, 1983.

    PubMed  CAS  Google Scholar 

  112. Quigley JP and Goldfarb RH. J. Cell Biol. 79: 73a, 1978.

    Google Scholar 

  113. Quigley JP, Goldfarb RH, Scheiner CJ, O’Donnell-Tormey J and Yeo TK. Prog. Clin. Biol. Res. 41: 773–796, 1980.

    PubMed  CAS  Google Scholar 

  114. Quigley JP. J. Cell Biol. 71 472–486, 1976.

    Article  PubMed  CAS  Google Scholar 

  115. Kramer RH, Vogel KG and Nicolson GL. J. Biol. Chem. 257 2678–2686, 1982.

    PubMed  CAS  Google Scholar 

  116. Nakajima M, Irimura T, DiFerrante D, DiFerrante N and Nicolson GL. Science 220; 611–613, 1983.

    Article  PubMed  CAS  Google Scholar 

  117. Vlodavsky I, Riks Z, Bar-Ner M, Ariav Y and Schirrmacher V. Cancer Res. 43. 2704–2711, 1983.

    PubMed  CAS  Google Scholar 

  118. Sloane BF, Honn KV, Sadler JG. Turner WA, Kimpson JJ and Taylor JD. Cancer Res. 42: 980–986, 1982.

    PubMed  CAS  Google Scholar 

  119. Sloane BF, Dunn JR and Honn KV. Science 212: 1151–1153, 1981.

    Article  PubMed  CAS  Google Scholar 

  120. Orr W, Varani J and Ward PA. An. J. Pathol. 93: 405–422, 1978.

    CAS  Google Scholar 

  121. Orr W, Varani J, Gondek MD, Ward PA and Mudny GR. Science 203 176–179, 1979.

    Article  PubMed  CAS  Google Scholar 

  122. Varani J and Ward PA. In: Tumor Invasion and Metastasis (Eds. Liotta LA and Hart IR), Martinus Nijhoff, The Hague, pp. 98–112, 1982.

    Google Scholar 

  123. Varani J. Cancer Metastasis Rev. 1: 17–28, 1982.

    Article  PubMed  CAS  Google Scholar 

  124. Thorgeirsson UP, Liotta LA, Kalebic T, Margulies IM, Thomas K, Rios-Candelore M and Russo RG. J. Natl. Cancer Inst. 69: 1049–1054, 1982.

    PubMed  CAS  Google Scholar 

  125. Russo RG, Thorgeirsson U and Liotta LA. In: Tumor Invasion and Metstasis (Eds. Uotta LA and Hart IR), Martinus Nijhoff, The Hague, pp. 173–187, 1982.

    Google Scholar 

  126. Weiss L and Ward PM. Cancer Metastasis Rev. 2: 111–127, 1983.

    Article  PubMed  CAS  Google Scholar 

  127. Lark MW and Culp LA. Biochemistry 22: 2289–2296, 1983.

    Article  PubMed  CAS  Google Scholar 

  128. Thomas CA Yost FJ, Snyderman R, Hatcher BB and Lazarus G. Nature (London) 269: 521–522, 1977.

    Article  CAS  Google Scholar 

  129. Hatcher VB, Lazarus GS, Levine N, Burk PG and Yost FJ. Biochim. Biophys. Acta. 483: 160–171, 1977.

    PubMed  CAS  Google Scholar 

  130. Bar-Shavit R, Kahn A, Wilner GD and Fenton JW. Science 220: 728–731, 1983.

    Article  PubMed  CAS  Google Scholar 

  131. Ossowski L, Quigley JP and Reich E. In: Proteases and Biological Control (Eds. Reich E, Rifkin DB and Shaw E), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp. 901–913, 1975.

    Google Scholar 

  132. Kalderon N. Proc. Natl. Acad. Sci. USA 76: 5992–5998, 1979.

    Article  CAS  Google Scholar 

  133. Moonen G, Brau-Wagemans MP and Selak I. Nature (London) 298: 753–755, 1982.

    Article  CAS  Google Scholar 

  134. Liotta LA, Foidart JM, Gehron-Robey P, Martin GR and Gullino PM. Lancet 2: 146–147 1979.

    Article  PubMed  CAS  Google Scholar 

  135. Siegal GP, Barsky SH, Terranova VP and Liotta LA. Invasion Metastasis 1: 54–70, 1981.

    PubMed  CAS  Google Scholar 

  136. Barsky SH, Togo S, Garbisa S and Uotta LA. Lancet 2: 296–297, 1983.

    Article  Google Scholar 

  137. Albrechtsen R, Nielsen M, Wewer U, Engvall E and Ruoslahti E. Cancer Res. 41: 5076–5081, 1981.

    PubMed  CAS  Google Scholar 

  138. Nelles LP and Schnebli HP. Invasion Metastasis 82: 113–123, 1982.

    Google Scholar 

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Authors
  1. Lance A. Liotta
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  2. Ronald H. Goldfarb
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Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, 210 Science Hall, Detroit, 48202, MI, USA

    Kenneth V. Honn

  2. Department of Pharmacology, Wayne State University, 540 East Canfield, Detroit, 48201, MI, USA

    Bonnie F. Sloane

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© 1984 Martinus Nijhoff Publishing, Boston

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Liotta, L.A., Goldfarb, R.H. (1984). Interaction of Tumor Cells with the Basement Membrane of Endothelium. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_21

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  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_21

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