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Uric Acid Perturbations in the Hemolytic Uremic Syndrome

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Acute Renal Disorders and Renal Emergencies

Part of the book series: Developments in Nephrology ((DINE,volume 7))

Abstract

Although hyperuricemia has been found in a large number of disorders, (1) its occurrence in the hemolytic uremic syndrome (HUS) is not generally appreciated. (2,3) In 1969, while performing studies of the transperitoneal movement of solute (4) (including uric acid) in children undergoing their initial dialysis, we observed marked hyperuricemia disproportionate to the degree of renal failure in two infants with HUS. We have subsequently confirmed these observations in a series of 26 children with HUS and have performed studies in rabbits in an effort to identify the mechanism(s) leading to hyperuricemia. This report has four objectives: 1) to review our experience with and interpretation of uric acid metabolism in patients with HUS, 2) to present data which provide information on possible mechanisms for the hyperuricemia, 3) to consider uric acid metabolism in experimental models of hemolysis and acute and chronic renal failure, and 4) to review available literature on the subject of uric acid metabolism in renal failure.

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Author information

Authors and Affiliations

  1. St. Christopher’s Hospital for Children, 5th & Lehigh Avenue, Philadelphia, PA, 19133, USA

    Alan B. Gruskin

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  1. Alan B. Gruskin
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  2. J. Lawrence Naiman
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  3. Martin S. Polinsky
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  4. Michael Mellon
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  5. H. Jorge Baluarte
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  6. Bruce A. Kaiser
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  7. Sharon A. Perlnan
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  8. Bruce Z. Morgenstern
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Editors and Affiliations

  1. Division of Pediatric Nephrology, School of Medicine, University of Miami, Miami, Florida, USA

    José Strauss MD

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© 1984 Martinus Nijhoff Publishing, Boston

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Gruskin, A.B. et al. (1984). Uric Acid Perturbations in the Hemolytic Uremic Syndrome. In: Strauss, J. (eds) Acute Renal Disorders and Renal Emergencies. Developments in Nephrology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3822-2_4

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  • DOI: https://doi.org/10.1007/978-1-4613-3822-2_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3824-6

  • Online ISBN: 978-1-4613-3822-2

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