Abstract
At the first course on tumours of the genito-urinary apparatus held in Erice in July of 1977, I presented preliminary results of the Veteran’s Administration randomised trial comparing placebo, pyridoxine and topical thiotepa in preventing recurrence of Stage I bladder tumours. Since that time, that trial has been completed and reported in the literature (1). My purpose today is to review these results with you particularly since they have stimulated a new trial to be performed by members of the EORTC Urological Group, scheduled to begin early in 1979.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Byar, D. P., Blackard, C., and the VACURG (Veterans Administration Cooperative Urological Research Group), Comparisons of placebo, pyridoxine, and topical thiotepa in preventing recurrence of Stage I bladder cancer. Urology, 10, 556 (1977).
Jones, H. C. and Swinney, J., Thio-TEPA in the treatment of tumours of the bladder. Lancet, 2, 615 (1961).
Veenema, R. J. et al, Bladder carcinoma treated by direct instillation of thio-TEPA. J. Urol. 88, 60 (1962).
Price, J. M. and Brown, R. R., Studies on the etiology of carcinoma of the urinary bladder. Acta Un. Int. Cancer, 18, 684 (1962).
Bryan, G. T., Brown, R. R. and Price, J. M., Mouse bladder carcinogenicity of certain tryptophan metabolites and other aromatic nitrogen compounds suspended in cholesterol. Cancer Res. 24, 596 (1964).
Brown, R. R., Price, J. M., Satter, E. J. and Wear, J. B., The metabolism of tryptophan in patients with bladder cancer. Acta Un. Int. Cancer, 16, 299 (1960).
Gehan, E. A., Statistical methods for survival time studies, in Staquet, M. J., Ed.: Cancer Therapy: Prognostic Factors and Criteria of Response, New York, Raven Press, 1975, p. 25.
Mantel, N., Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother. Rep. 50, 163 (1966).
Romas, N. A. et al, Anergy and tryptophan metabolism in bladder cancer. J. Urol. 115, 387 (1976).
Gailani, S. et al, Studies on tryptophan metabolism in patients with bladder cancer. Cancer Res. 33, 1071 (1973).
Benassi, C. A. et al, The metabolism of tryptophan in patients with bladder cancer and other urological diseases. Clin. Chim. Acta 8, 822 (1963).
Teulings, F. A. et al, A new aspect of the urinary excretion of tryptophan metabolites in patients with cancer of the bladder. Int. J. Cancer 21, 140 (1978).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Press, New York
About this chapter
Cite this chapter
Byar, D.P. (1980). The Veterans Administration Study of Chemoprophylaxis for Recurrent Stage I Bladder Tumours: Comparisons of Placebo, Pyridoxine and Topical Thiotepa. In: Pavone-Macaluso, M., Smith, P.H., Edsmyr, F. (eds) Bladder Tumors and other Topics in Urological Oncology. Ettore Majorana International Science Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3030-1_74
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3030-1_74
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3032-5
Online ISBN: 978-1-4613-3030-1
eBook Packages: Springer Book Archive