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Interaction of Viruses with Neutralizing Antibodies

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Comprehensive Virology

Abstract

Possibly the earliest published expectation and demonstration of the neutralizing capacity of humoral antibody is contained in the report of Sternberg (1892). He suspected that the blood of an individual recently recovered from a viral infection contained an “antitoxine” that could nullify the infectious capability of the causative agent. He then demonstrated that the serum of a calf recently vaccinated with cowpox (?) virus neutralized the infectivity of this virus when the two were mixed prior to inoculation. The validity of this result was corroborated, and extended, by Béclère et al. (1898) in their studies involving a different host, man, and a different virus, variola. Worthy of note is the empirical aspect of these speculations and experimentations since the nature of antibody as well as virus was at that time unknown.

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Authors and Affiliations

  1. Department of Virology, The Public Health Research Institute of the City of New York, Inc., New York, New York, 10016, USA

    Benjamin Mandel

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  1. Benjamin Mandel
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  1. Department of Molecular Biology and Virus Laboratory, University of California, Berkeley, California, USA

    Heinz Fraenkel-Conrat

  2. Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA

    Robert R. Wagner

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© 1979 Plenum Press, New York

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Mandel, B. (1979). Interaction of Viruses with Neutralizing Antibodies. In: Fraenkel-Conrat, H., Wagner, R.R. (eds) Comprehensive Virology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3009-7_2

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  • DOI: https://doi.org/10.1007/978-1-4613-3009-7_2

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