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Choline Availability — Choline High Affinity Transport and the Regulation of Acetylcholine Synthesis

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Brain Acetylcholine and Neuropsychiatric Disease

Abstract

The use of precursor-loading with choline as a therapeutic modality raises the question of whether the plasma levels of choline directly regulate the synthesis of (ACh) in brain. In this chapter, the issues of choline availability and the transport of choline by cholinergic nerve endings in the regulation of (ACh) formation will be discussed. Data are presented which suggest that under normal physiological conditions brain ACh levels and turnover are not regulated by the levels of free choline in plasma and that the physiologic regulatory step in ACh synthesis is the high affinity uptake of choline by cholinergic nerve endings.

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  1. Department of Pharmacology, Mt. Sinai School of Medicine, City University of New York, New York, N.Y., 10029, USA

    L. A. Barker

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  1. Veterans Administration Hospital, Palo Alto, California, 94304, USA

    Kenneth L. Davis  & Philip A. Berger  & 

  2. Stanford University School of Medicine, Stanford, California, 94305, USA

    Kenneth L. Davis  & Philip A. Berger  & 

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Barker, L.A. (1979). Choline Availability — Choline High Affinity Transport and the Regulation of Acetylcholine Synthesis. In: Davis, K.L., Berger, P.A. (eds) Brain Acetylcholine and Neuropsychiatric Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2934-3_29

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  • DOI: https://doi.org/10.1007/978-1-4613-2934-3_29

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