Skip to main content
SpringerLink
Log in

Release of Bioactive Agents from Swellable Polymers: Theory and Experiments

  • Chapter
Recent Advances in Drug Delivery Systems

Abstract

In the past twenty years we have seen a considerable increase in the number of research studies, publications and patents in the area of controlled release systems for pharmaceutical applications. Langer and Peppas (1–3) and Peppas and Gurny (4) have reviewed various aspects of the preparation, structure and biocompatibility of polymers for pharmaceutical applications and have established methods for incorporation of drugs in and kinetic behavior from different types of controlled release devices. Other chapters in this book provide extensive analysis and experimental results of a variety of controlled release, drug-delivery polymeric systems.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R.S. Langer, Chem. Eng. Commun. 6: 1 (1980).

    Article  Google Scholar 

  2. R.S. Langer, N.A. Peppas, Biomaterials 2: 201 (1981).

    Article  PubMed  Google Scholar 

  3. R.S. Langer, N.A. Peppas, J. Macromol. Sci., Rev. Macromol. Chem. 16: 000 (1983).

    Google Scholar 

  4. N.A. Peppas, R. Gurny, Pharm. Acta Helv. 58: 2 (1983).

    PubMed  Google Scholar 

  5. N.A. Peppas, Controlled Drug Bioavailability 1: 000 (1983).

    Google Scholar 

  6. N.A. Peppas, in “Medical Applications of Controlled Release Technology”, R.S. Langer, D. Wise, eds., CRC Press, Boca Raton, FL, in press.

    Google Scholar 

  7. W.D. Rhine, V. Sukhatme, D.S.T. Hsieh, R.S. Langer, in “Controlled Release of Bioactive Materials”, R. Baker, ed., Academic Press, New York, NY, p. 177 (1980).

    Google Scholar 

  8. E.A. Swan, N.A. Peppas, Proc. Symp. Cont. Rel. Bioact. Mater. 8: 18 (1981).

    Google Scholar 

  9. R. Gurny, E. Doelker, N.A. Peppas, Biomaterials 3: 27 (1982).

    Article  PubMed  Google Scholar 

  10. N.A. Peppas, J. Biomed. Mater. Res. 17: 000 (1983).

    Article  Google Scholar 

  11. S.K. Chandrasekaran, D.R. Paul, J. Pharm. Sci. 71: 1399 (1982)

    Article  PubMed  Google Scholar 

  12. H.B. Hopfenberg, in “Controlled Release Polymerie Formulations” D.R. Paul, F.W. Harris, eds., ACS Symposium Series, Vol. 33, ACS, Washington, D.C., p. 26 (1976).

    Chapter  Google Scholar 

  13. F. Theeuwes, in “Controlled Release Technologies”, A.F. Kydonieus, ed., Vol. 2, CRC Press, Boca Raton, FL, p. 195 (1981).

    Google Scholar 

  14. R.W. Korsmeyer, N.A. Peppas, in “Controlled Release Delivery Systems”, S.Z. Mansdorf, T.J. Roseman, eds., M. Dekker, New York, NY, p. 77 (1983).

    Google Scholar 

  15. J.L. Salomon, E. Doelker, Pharm. Acta Helv. 55: 174 (1980).

    Google Scholar 

  16. J.T. Carstensen, J.P. Marty, F. Puisieux, H. Fessi, J. Pharm. 70: 222 (1981).

    Google Scholar 

  17. M. Bamba, F. Puisieux, J.P. Marty, J.T. Carstensen, Intern. J. Pharm. 2: 87 (1979). 18. M. Bamba, F. Puisieux, J.P. Marty, J.T. Carstensen, Intern. J. Pharm. 2: 307 (1979).

    Article  Google Scholar 

  18. M. Bamba, F. Puisieux, J.P. Marty, J.T. Carstensen, Intern. J. Pharm. 2: 307 (1979).

    Article  Google Scholar 

  19. C. Brossard, J.T. Carstensen, D. Lefort des Ylouses, D. Duchene, Proc. Europ. Congr. Biopharm. Pharmacokin. 9: 278 (1981).

    Google Scholar 

  20. J.L. Salomon, P. Vuagnat, E. Doelker, P. Buri, Pharm. Acta Helv. 54: 86 (1979).

    PubMed  Google Scholar 

  21. J.L. Salomon, E. Doelker, P. Buri, Pharm. Acta Helv. 54: 82 (1979).

    PubMed  Google Scholar 

  22. R.W. Korsmeyer, R. Gurny, E. Doelker, P. Buri, N.A. Peppas, J. Pharm. Sci. 72: 000 (1983).

    Article  Google Scholar 

  23. R.W. Korsmeyer, R. Gurny, E. Koelker, P. Buri, N.A. Peppas, Intern. J. Pharm. 14: 000 (1983).

    Google Scholar 

  24. R. Gurny, E. Doelker, P. Buri, R.W. Korsmeyer, N.A. Peppas, Proc. Intern. Conf. Pharm. Technol. 3: 000 (1983).

    Google Scholar 

  25. N.A. Peppas, N.M. Franson, J. Polym. Sci., Polym. Phys. 21: 000 (1983).

    Google Scholar 

  26. N.M. Franson, N.A. Peppas, J. Appl. Polym. Sci. 28: 000 (1983).

    Article  Google Scholar 

  27. H.B. Hopfenberg, K.C. Hsu, Polym. Eng. Sci. 18: 1186 (1978).

    Article  Google Scholar 

  28. H.B. Hopfenberg, Proc. Intern. Symp. Cont. Rel. Bioact. Mater. 8: 79 (1981).

    Google Scholar 

  29. T. Alfrey, E.F. Gurnee, W.G. Lloyd, J. Polym. Sci. C12: 249 (1966).

    Google Scholar 

  30. H.B. Hopfenberg, H.L. Frisch, J. Polym. Sci. B7: 405 (1969).

    Article  Google Scholar 

  31. T.T. Wang, T.K. Kwei, H.L. Frisch, J. Polym. Sci. 12: 2019 (1969).

    Google Scholar 

  32. T.K. Kwei, T.T. Wang, H.M. Zupko, Macromolecules 5: 645 (1972).

    Article  Google Scholar 

  33. J.S. Vrentas, C.M. Jarzebski, J.L. Duda, J. Polym. Sci., Polym. Phys. 15: 441 (1977).

    Google Scholar 

  34. A. Peterlin, Makromol. Chemie 124: 136 (1969).

    Article  Google Scholar 

  35. A. Peterlin, Polym. Eng. Sci. 20: 238 (1980).

    Article  Google Scholar 

  36. G. Astarita, G.C. Sarti, Polym. Eng. Sci. 18: 388 (1978).

    Article  Google Scholar 

  37. G.C. Sarti, Polymer 20: 827 (1979).

    Article  Google Scholar 

  38. N.L. Thomas, A.H. Windle, Polymer 21: 613 (1980).

    Article  Google Scholar 

  39. N.L. Thomas, A.H. Windle, Polymer 23: 529 (1982).

    Article  Google Scholar 

  40. C. Gostoli, G.C. Sarti, Polym. Eng. Sci. 22: 1018 (1982).

    Article  Google Scholar 

  41. C. Gostoli, G.C. Sarti, Chem. Eng. Commun., in press.

    Google Scholar 

  42. N.A. Peppas, J.L. Sinclair, Coll. Polym. Sci. 261: 000 (1983).

    Article  Google Scholar 

  43. R.W. Korsmeyer, Ph.D. Thesis, School of Chemical Engineering, Purdue University, W. Lafayette, IN, 1983.

    Google Scholar 

  44. N.A. Peppas, R. Gurny, E. Doelker, P. Buri, J. Membr. Sci. 7: 241 (1980).

    Article  Google Scholar 

  45. P.I. Lee, J. Membr. Sci. 7: 255 (1980).

    Article  Google Scholar 

  46. N.A. Peppas, Org. Coat. Appl. Polym. Sci. Proc. 46: 615 (1982).

    Google Scholar 

  47. G. Astarita, S. Joshi, J. Membr. Sci. 4: 165 (1978).

    Article  Google Scholar 

  48. J.D. Ferry, “Viscoelastic Properties of Polymers”, p. 316, Wiley, New York, NY (1970).

    Google Scholar 

  49. H.B. Hopfenberg, AIChE Symp. Series 206: 37 (1981).

    Google Scholar 

  50. W.R. Good, in “Polymeric Delivery Systems”, R. Kostelnik, ed., Gordon and Breach, New York, NY, p. 139 (1976).

    Google Scholar 

  51. R.W. Korsmeyer, N.A. Peppas, J. Membr. Sci. 9: 211 (1981).

    Article  Google Scholar 

  52. R.W. Korsmeyer, N.A. Peppas, Proc. Symp. Cont. Rel. Bioact. Mater. 8: 85 (1981).

    Google Scholar 

  53. R.W. Korsmeyer, T.L. Rave, N.A. Peppas, R. Gurny, E. Doelker, P. Buri, Proc. Symp. Cont. Rel. Bioact. Mater. 9: 65 (1982).

    Google Scholar 

  54. H.B. Hopfenberg, A. Apicella, D.E. Saleeby, J. Membr. Sci. 8: 273 (1981).

    Article  Google Scholar 

  55. A. Apicella, H.B. Hopfenberg, J. Appl. Polym. Sci. 27: 1139 (1983).

    Article  Google Scholar 

  56. A. Apicella, H.B. Hopfenberg, S. Piccarolo, Polym. Eng. Sci. 22: 382 (1982).

    Article  Google Scholar 

  57. S. Gaeta, A. Apicella, H.B. Hopfenberg, J. Membr. Sci. 12: 195 (1982).

    Article  Google Scholar 

  58. C.T. Reinhart, R.W. Korsmeyer, N.A. Peppas, Intern. J. Pharm. Tech. 2(2): 9 (1981).

    Google Scholar 

  59. N.M. Franson, N.A. Peppas, Polym. Prepr. 24: 000 (1983).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Chemical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA

    Nikolaos A. Peppas

Authors
  1. Nikolaos A. Peppas
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    James M. Anderson

  2. University of Utah, Salt Lake City, Utah, USA

    Sung Wan Kim

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag US

About this chapter

Cite this chapter

Peppas, N.A. (1984). Release of Bioactive Agents from Swellable Polymers: Theory and Experiments. In: Anderson, J.M., Kim, S.W. (eds) Recent Advances in Drug Delivery Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2745-5_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2745-5_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9700-0

  • Online ISBN: 978-1-4613-2745-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation