Abstract
One of the basic problems in biology is the question of how the initiation, regulation and termination of DNA synthesis and cell division occur in growth and aging. For the ventricular myocyte, cell division is thought to cease in a number of species shortly after birth (1). During the postnatal growth period, division of cardiac myocytes may result in the formation of a diversity of myocyte types. In the rat, binucleated cells (2,3) and a small percentage of polyploid cells (4) may result. In the human, polyploidization of ventricular myocytes to 4N occurs between the seventh and twelfth year (5). In the pig, postnatal division results in multinucleated myocytes (6,7). Thus, mononucleated myocytes appear early in development with binucleated, multinucleated and polyploid cells often appearing later.
This work was supported in part by a grant from the North Dakota Affiliate of the American Heart Association.
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Oberpriller, J.O., Ferrans, V.J., McDonnell, T.J., Oberpriller, J.C. (1985). Activation of DNA Synthesis and Mitotic Events in Atrial Myocytes Following Atrial and Ventricular Injury. In: Stone, H.L., Weglicki, W.B. (eds) Pathobiology of Cardiovascular Injury. Developments in Cardiovascular Medicine, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2621-2_30
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