Abstract
For molecular design of blood-compatible surfaces it is essential to have knowledge of the mechanism of clotting occurring on the foreign surfaces. The recent progress on the biochemistry of blood coagulation has disclosed much of primary reactions involved in the complicated cascade process of thrombus formation. Although platelet adhesion as well as the activation of Hageman factor (XII) by high-molecular-weight kininogen and prekallikrein, are not completely made clear in the molecular level, it is well known that the thrombus formation is triggered by an interaction between blood components and the foreign polymer surface1). It is not clear which blood component plays a decisive role in the trigger reaction, but the key reaction seems to involve some plasma proteins which will be adsorbed within a few seconds to a polymer surface brought into contact with blood. Platelet adhesion may follow the protein adsorption. Therefore, the adsorption of plasma proteins to polymer surfaces has been the objective of numerous investigations2).
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Ikada, Y., Suzuki, M., Tamada, Y. (1984). Polymer Surfaces Possessing Minimal Interaction with Blood Components. In: Shalaby, S.W., Hoffman, A.S., Ratner, B.D., Horbett, T.A. (eds) Polymers as Biomaterials. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2433-1_10
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DOI: https://doi.org/10.1007/978-1-4613-2433-1_10
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