Skip to main content

Intracellular Translocation of Inorganic Particles

  • Chapter
The Cytoskeleton

Abstract

A variety of inorganic particles may be inhaled during environmental or occupational exposures. A number of studies with animals have shown that inhaled toxic particles such as silica (Brody et al., 1982) and asbestos (Brody et al., 1981; Brody and Hill, 1982) accumulate in the lung interstitium soon after exposure. The presence of interstitial asbestos is known to induce the progression of fibrotic scarring (Selikoff and Lee, 1978) by undefined mechanisms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adler, K.B., Brody, A.R. and Craighead, J.E., 1981, Studies on the mechanism of mucin secretion by cells of the porcine tracheal epithelium, Proc. Soc. Exp. Biol. Med., 166:96–10.

    Google Scholar 

  • Adler, K.B., Craighead, J.E., Yallyathan, N.Y. and Evans, J.N., 1981, Actin-containing cells in human pulmonary fibrosis, Amer. J. Pathol., 102:42 7–43.

    Google Scholar 

  • Barrett, J.C., Crawford, B.D., Grady, D.L., Hester, L.D., Jones, P.A., Benedict, W.F. and Ts’o, P.O.P., Temporal acquisition of enhanced fibrinolytic activity by Syrian hamster embryo cells following treatment with benzo(a)pyrene, Cancer Res., 37: 3815–382.

    Google Scholar 

  • Brody, A.R., 1984, The early pathogenesis of asbestos-induced lung disease, Scan Elect. Mic., 1: 167–17.

    Google Scholar 

  • Brody, A.R. and Hill, 1982, Interstitial accumulation of inhaled chrysotile asbestos fibers and consequent formation of microcalcifications, Amer. J. Pathol., 109:107–11.

    Google Scholar 

  • Brody, A.R. and Roe, M.W., 1983, Deposition pattern of inorganic particles at the alveolar level in the lungs of rats and mice, Amer. Rev. Resp. Dis., 128:724–72.

    Google Scholar 

  • BrodyTXR., Hill, L.H., Adkins, B. and O’Connor, R.W., 1981, Chrysotile asbestos inhalation in rats: Deposition pattern and reaction of alveolar epithelium and pulmonary macrophages, Amer. Rev. Resp. Pis., 123:670–67.

    Google Scholar 

  • Brody, A.R., Roe, M.W., Evans, J.N. and Davis, G.S., 1982, Deposition and translocation of inhaled silica in rats: quantification of macrophage participation and particle distribution in alveolar ducts. Lab. Invest., 47:533–54.

    Google Scholar 

  • Brody, A.R., Hill, L.H. and Adler, K.B., 1983, Actin-containing microfilaments of pulmonary epithelial cells provide a mechanism for translocating asbestos to the interstitium, Chest, 83: 11–1.

    CAS  Google Scholar 

  • Craighead, J.E. and Mossman, B.T., 1982, The pathogenesis of asbestos-associated diseases, N. Eng. J. Med., 306:1446–145.

    Google Scholar 

  • Hartwig, J.H., Davies, W.A. and Stossel, T.P., 1977, Evidence for contractile protein translocation in macrophage spreading, phagocytosis and phagolysosome formation, J. Cell Biol., 75:956–96.

    Google Scholar 

  • Hesterberg, T.W. and Barrett, J.C., 1984, Dependence of asbestos and mineral dust-induced transformation of mammalian cells in culture on fiber dimension, Cancer Res., 44: 2170–218.

    Google Scholar 

  • Hesterberg, T.W., Cummings, T., Brody, A.R. and Barrett, J.C., 1982, Asbestos induces morphological transformation of Syrian hamster embryo cells in culture, J. Cell Biol., 95:449.

    Google Scholar 

  • Mossman, B.T., Ezerman, E.B., Adler, K.B. and Craighead, J.E., 1980, Isolation and spontaneous transformation of cloned lines of hamster tracheal epithelial cells, Cancer Res., 40: 4403–440.

    Google Scholar 

  • Oshimura, M., Hesterberg, T.W., Tsutsui, T. and Barrett, J.C., 1985, Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture. Cancer Res, (in press).

    Google Scholar 

  • Selikoff, I.J. and Lee, D.H.K., 1982, “Asbestos and Disease,” Academic Press, New York.

    Google Scholar 

  • Trotter, J.A., 1981, The organization of actin in spreading macrophages, Exp. Cell Res., 132:235–24.

    Google Scholar 

  • Tsilibary, E.C. and Williams, M.C., 1983, Actin in peripheral rat lung: Si labeling and structural changes induced by cytochalasin, Histochem. Cytochem., 11: 1289–129.

    Article  Google Scholar 

  • Warheit, D.B., Hill, L.H. and Brody, A.R., 1983, Pulmonary macrophage phagocytosis: Quantification by secondary and backscattered electron imaging, Scan. Elect. Mic., 4:431–43.

    Google Scholar 

  • Warheit, D.B., Chang, L.Y., Hill, L.H., Hook, G.E.R., Crapo, J.D., and Brody, A.R., 1984, Pulmonary macrophage accumulation and asbestos-induced lesions at sites of fiber deposition, Amer. Rev. Resp. Pis., 129:301–31.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Brody, A.R., Hill, L.H., Hesterberg, T.W., Barrett, J.C., Adler, K.B. (1986). Intracellular Translocation of Inorganic Particles. In: Clarkson, T.W., Sager, P.R., Syversen, T.L.M. (eds) The Cytoskeleton. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2161-3_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2161-3_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9274-6

  • Online ISBN: 978-1-4613-2161-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics