Abstract
The germ-line of species is immortal, at least in the sense that an unbroken continuity extends backwards in time to the origin of terrestrial life and forwards in time to an indeterminate future. This observation is a truism. However, when set against the fact that the bodies of higher animals are intrinsically mortal, yet composed of the same basic materials as their germ cells, the observation leads to the central puzzle of gerontology. Each new-born individual begins its life as young as did each of its ancestors but with the same certitude, if it does not meet with an earlier accident, that within a specific span of time it will arrive, through a process of steadily accelerating decrepitude, at death. The puzzle has two sides: why and how has the somatic part of higher animals come to be mortal, and how is the germ-line kept free of the progressive deterioration in the soma?
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References
Bernstein, H., 1977, Germ line recombination may be primarily a manifestation of DNA repair processes, J. Theor. Biol., 69:371
Charlesworth, B., 1980, “Evolution in Age-Structured Populations,” Cambridge University Press, Cambridge.
Comfort, A., 1979, “The Biology of Senescence,” 3rd edition, Churchill Livingstone, Edinburgh.
Francis, A. A., Lee, W. H., and Regan, J. D., 1981, The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum lifespan of mammals, Mech. Ageing Dev., 16:181.
Haldane, J. B. S., 1941, “New Paths in Genetics,” Allen and Unwin, London.
Hall, K. Y., Hart, R. W., Benirschke, A. K., and Walford, R. L., 1984, Correlation between ultraviolet-induced DNA repair in primate lymphocytes and species maximum achievable lifespan, Mech. Ageing Dev., 24:163.
Hart, R. W., and Setlow, R. B., 1974, Correlation between deoxyribonucleic acid excision repair and lifespan in a number of mammalian species, Proc. Nat. Acad. Sci., U.S.A., 71:2169.
Kirkwood, T. B. L., 1977, Evolution of ageing, Nature, 270:301.
Kirkwood, T. B. L., 1981, Repair and its evolution: survival versus reproduction, in: “Physiological Ecology: An Evolutionary Approach to Resource Use,” C. R. Townsend and P. Calow, eds., Blackwell Scientific Publications, Oxford.
Kirkwood, T. B. L., 1985, Comparative and evolutionary aspects of longevity, in: “Handbook of the Biology of Aging,” C. E. Finch and E. L. Schneider, eds., Van Nostrand Reinhold, New York.
Kirkwood, T. B. L., and Cremer, T., 1982, Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress, Hum. Genet., 60:101.
Kirkwood, T. B. L., and Holliday, R., 1979, The evolution of ageing and longevity, Proc. Roy. Soc., Lond., B205:531.
Kirkwood, T. B. L., and Holliday, R., 1986, Ageing as a consequence of natural selection, in: “The Biology of Human Ageing,” K. J. Collins and A. H. Bittles, eds., Cambridge University Press, Cambridge.
Medawar, P. B., 1952, “An Unsolved Problem in Biology,” H. K. Lewis, London.
Medvedev, Z. A., 1981, On the immortality of the germ line: genetic and biochemical mechanisms. A review, Mech. Ageing Dev., 17:331.
Reichman, O. J., 1984, Evolution of regeneration capabilities, Am. Nat., 123:752.
Sacher, G. A., 1978, Evolution of longevity and survival characteristics in mammals, in: “The Genetics of Aging,” E. L. Schneider, ed., Plenum, New York.
Sheldrake, A. R., 1974, The ageing, growth and death of cells, Nature, 250:381.
Topp, W., Hall, J. D., Rifkin, D., Levine, A. J., and Pollack, R., 1977, The characterisation of SV40-transformed cell lines derived from mouse teratocarcinoma: growth properties and differentiated characteristics, J. Cell. Physiol., 93–269.
Townsend, C. R., and Calow, P. C., 1981, “Physiological Ecology: An Evolutionary Approach to Resource Use,” Blackwell Scientific Publications, Oxford.
Treton, J. A., and Courtois, Y., 1982, Correlation between DNA excision repair and mammalian lifespan in lens epithelial cells, Cell Biol. Int. Rep., 6:253.
Weismann, A., 1890, Untitled correspondence, Nature, 41:317 (reprinted as Appendix 2 in Kirkwood, T. B. L., and Cremer, T., 1982, cited above).
Williams, G. C., 1957, Pleiotropy, natural selection and the evolution of senescence, Evolution, 11:398.
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© 1987 Plenum Press, New York
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Kirkwood, T.B.L. (1987). Immortality of the Germ-Line versus Disposability of the Soma. In: Woodhead, A.D., Thompson, K.H. (eds) Evolution of Longevity in Animals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1939-9_15
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DOI: https://doi.org/10.1007/978-1-4613-1939-9_15
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