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Dipyridamole-Echocardiography Test

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Echocardiography in Coronary Artery Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 80))

Abstract

Dipyridamole is a potent coronary arteriolar vasodilator that has been employed in combination with thallium-201 imaging for the detection of coronary artery disease [1]. Since a coronary stenosis may significantly reduce the regional coronary reserve without inducing ischemia, the presence of coronary artery disease can be documented by the different uptake of a flow tracer, such as thallium 201. Theoretically, myocardial ischemia is not required for the dipyridamole-thallium test to be positive. However, dipyridamole infusion can also induce myocardial ischemia in the presence of a coronary obstruction. This has been shown by a large amount of experimental [2] and clinical [3–5] evidence. At a dosage of 0.75 mg/kg over 10 min, the electrocardiogram (ECG)-dipyridamole stress test has been proposed for the diagnosis of coronary artery disease, with a diagnostic accuracy comparable to the exercise stress test and an overall sensitivity (ECG changes and/or anginal pain) of ~80% [5],

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Authors
  1. Eugenio Picano
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Editor information

Editors and Affiliations

  1. Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands

    Cees A. Visser M.D.  & Gerard Kan M.D.  & 

  2. Department of Medicine and Radiology and the Center for Biomedical Ultrasound, Rochester, New York, 14642, USA

    Richard S. Meltzer M.D.

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© 1988 Kluwer Academic Publishers. Boston/Dordrecht/Lancaster

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Picano, E. (1988). Dipyridamole-Echocardiography Test. In: Visser, C.A., Kan, G., Meltzer, R.S. (eds) Echocardiography in Coronary Artery Disease. Developments in Cardiovascular Medicine, vol 80. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1767-8_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1767-8_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8991-3

  • Online ISBN: 978-1-4613-1767-8

  • eBook Packages: Springer Book Archive

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