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Tumor-associated growth factors in malignant rodent and human mammary epithelial cells

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Breast Cancer: Cellular and Molecular Biology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 40))

Abstract

Before considering the potential role of tumor-derived growth factors in regulating the proliferation of rodent and human mammary epithelial cells, it is important to emphasize several important aspects concerning the in vivo biology of the normal mammary gland. First, the mammary gland is not a static organ but is relatively dynamic. It periodically undergoes cycles of growth, development, differentiation, and regression. These cyclical events, which occur primarily during pregnancy and lactation, are in large part controlled by a complex interplay of various polypeptide and steroid hormones [1]. Super-imposed upon this endocrine background are proliferative and differentiation controls which might be exerted by several peptide growth factors. These growth factors may originate from tissues outside of the mammary gland in an endocrine fashion or they may be derived locally from within the gland as products of discrete cell types acting as either paracrine or autocrine factors [2–6]. This raises a second important point, namely that the mammary gland is not homogeneous but is a heterogenous tissue in which the mammary epithelial and myoepithelial cells are embedded within an adipose and mesenchymal stroma and separated from this compartment by a basal lamina or basement membrane.

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Authors
  1. David S. Salomon
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  2. William R. Kidwell
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  1. National Cancer Institute, USA

    Marc E. Lippman  & Robert B. Dickson  & 

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Salomon, D.S., Kidwell, W.R. (1988). Tumor-associated growth factors in malignant rodent and human mammary epithelial cells. In: Lippman, M.E., Dickson, R.B. (eds) Breast Cancer: Cellular and Molecular Biology. Cancer Treatment and Research, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1733-3_17

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