Abstract
Tumor invasion and metastases is the major cause of treatment failure for cancer patients. Approximately 30% of patients with newly diagnosed solid tumors (excluding skin cancers other than melanoma) already have clinically detectable metastases. This percentage has increased somewhat in recent years due to the widespread adoption of new imaging technology resulting in the detection of metastases at an earlier stage in their growth. Of those 60% of cancer patients which are clinically free of metastases, approximately half can be cured by local tumor therapy alone [1]. The remaining patients have clinically occult micrometastases which ultimately become manifest. The patient with metastatic disease succumbs to the direct anatomic compromise caused by the metastases or to complications associated with therapy.
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© 1988 Kluwer Academic Publishers, Boston/Dordrecht/London
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Liotta, L.A., Stracke, M.L. (1988). Tumor invasion and metastases: biochemical mechanisms. In: Lippman, M.E., Dickson, R.B. (eds) Breast Cancer: Cellular and Molecular Biology. Cancer Treatment and Research, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1733-3_10
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DOI: https://doi.org/10.1007/978-1-4613-1733-3_10
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